ID   GIP2_CAEEL              Reviewed;         642 AA.
AC   G5EF84;
DT   11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Gamma-tubulin interacting protein 2 {ECO:0000312|WormBase:C45G3.5};
GN   Name=gip-2 {ECO:0000312|WormBase:C45G3.5};
GN   ORFNames=C45G3.5 {ECO:0000312|WormBase:C45G3.5};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=26586219; DOI=10.1242/dev.126615;
RA   Quintin S., Wang S., Pontabry J., Bender A., Robin F., Hyenne V.,
RA   Landmann F., Gally C., Oegema K., Labouesse M.;
RT   "Non-centrosomal epidermal microtubules act in parallel to LET-502/ROCK to
RT   promote C. elegans elongation.";
RL   Development 143:160-173(2016).
CC   -!- FUNCTION: Recruited to hemidesomosomes in early embryonic elongation to
CC       direct the nucleation and growth of non-centrosomal microtubules.
CC       {ECO:0000269|PubMed:26586219}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, hemidesmosome
CC       {ECO:0000269|PubMed:26586219}. Cell junction, adherens junction
CC       {ECO:0000269|PubMed:26586219}.
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DR   EMBL; BX284601; CAI46549.1; -; Genomic_DNA.
DR   RefSeq; NP_001021044.1; NM_001025873.4.
DR   AlphaFoldDB; G5EF84; -.
DR   SMR; G5EF84; -.
DR   IntAct; G5EF84; 2.
DR   STRING; 6239.C45G3.5; -.
DR   EPD; G5EF84; -.
DR   PaxDb; G5EF84; -.
DR   PeptideAtlas; G5EF84; -.
DR   EnsemblMetazoa; C45G3.5.1; C45G3.5.1; WBGene00044008.
DR   GeneID; 3564968; -.
DR   KEGG; cel:CELE_C45G3.5; -.
DR   CTD; 3564968; -.
DR   WormBase; C45G3.5; CE37812; WBGene00044008; gip-2.
DR   eggNOG; KOG3159; Eukaryota.
DR   HOGENOM; CLU_429104_0_0_1; -.
DR   InParanoid; G5EF84; -.
DR   OMA; EYTECQD; -.
DR   OrthoDB; 441058at2759; -.
DR   PRO; PR:G5EF84; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00044008; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0030056; C:hemidesmosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   Cell junction; Microtubule; Reference proteome.
FT   CHAIN           1..642
FT                   /note="Gamma-tubulin interacting protein 2"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000436097"
SQ   SEQUENCE   642 AA;  73376 MW;  B196E049675A2D11 CRC64;
     MMRTAHKDRE PWRDIRRSLL SKWQGVRVCD EPSPWYMSIP TPFSQFHNVL PEEQEEMVFT
     ELKLFLVGNQ TENIRIDEYD KHDLPISILA NISFDPFIRS ELERFHDILV TVATIKICCY
     AITHDSVTFS SISSAVASTI EKKVNGFITK ICTKLSGSTE ANQQMNQLLR EMHTIHESLN
     FYNGIVKSIY LDQLIGGQVL SLLDSKRRHV FSGNVVQNLD DVFQAGWKVF ARSIGRLVCK
     FEADHMDYEF VIWSTKQMTD SQCKTLVPSN PSRQIKSSRY VVIESLCPDF FKKYLDILVR
     CAEFGDSAKS DSSLRRSTSK KINESESVES VMEDVRNVDW SNLDVATTVR MLVQFSRKES
     ACLLREITSA TNVDQAIRDI HDLLIKGSCA HDVMLFGLKA DILQKPIDEV GNIRMKKLTN
     DVLGAAAEKH HPFWKYFSFV IDKQNVFEML GQRTSLGGNA DNLRDNVTPM LFECISVKMD
     CPIEIEPIIS MKAVFILTPV FRIWIQLHVA SYTIANYRDS IRGQMPSRSL GDIAMKKHLM
     HALDAEISSI KQKWVGYVDL LINLYYERIQ KAASLDEYTE CQDILASDVT NMMGISELSQ
     LENIKDILNI IWNYDNADSN LADLIADFEE VQSRARMDVV VA