GIPC2_MOUSE
ID GIPC2_MOUSE Reviewed; 314 AA.
AC Q9Z2H7; Q9CVG2;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=PDZ domain-containing protein GIPC2;
DE AltName: Full=SemaF cytoplasmic domain-associated protein 2;
DE Short=SEMCAP-2;
GN Name=Gipc2; Synonyms=Semcap2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INTERACTION WITH
RP SEMA5A.
RX PubMed=10318831; DOI=10.1074/jbc.274.20.14137;
RA Wang L.-H., Kalb R.G., Strittmatter S.M.;
RT "A PDZ protein regulates the distribution of the transmembrane semaphorin,
RT M-SemF.";
RL J. Biol. Chem. 274:14137-14146(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Amnion, Small intestine, and Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Probably interacts with SEMA5A. {ECO:0000269|PubMed:10318831}.
CC -!- INTERACTION:
CC Q9Z2H7; Q64151: Sema4c; NbExp=3; IntAct=EBI-987119, EBI-987075;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in kidney and lung (at protein level).
CC {ECO:0000269|PubMed:10318831}.
CC -!- SIMILARITY: Belongs to the GIPC family. {ECO:0000305}.
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DR EMBL; AF061262; AAC72310.1; -; mRNA.
DR EMBL; AK008307; BAB25591.1; -; mRNA.
DR EMBL; AK008626; BAB25788.1; -; mRNA.
DR EMBL; AK168560; BAE40433.1; -; mRNA.
DR EMBL; BC013440; AAH13440.1; -; mRNA.
DR CCDS; CCDS17914.1; -.
DR RefSeq; NP_058563.1; NM_016867.1.
DR PDB; 5V6H; X-ray; 3.60 A; A/C/E/G/I=240-314.
DR PDBsum; 5V6H; -.
DR AlphaFoldDB; Q9Z2H7; -.
DR SMR; Q9Z2H7; -.
DR IntAct; Q9Z2H7; 3.
DR STRING; 10090.ENSMUSP00000037328; -.
DR iPTMnet; Q9Z2H7; -.
DR PhosphoSitePlus; Q9Z2H7; -.
DR EPD; Q9Z2H7; -.
DR jPOST; Q9Z2H7; -.
DR MaxQB; Q9Z2H7; -.
DR PaxDb; Q9Z2H7; -.
DR PeptideAtlas; Q9Z2H7; -.
DR PRIDE; Q9Z2H7; -.
DR ProteomicsDB; 267799; -.
DR Antibodypedia; 19742; 247 antibodies from 29 providers.
DR DNASU; 54120; -.
DR Ensembl; ENSMUST00000046614; ENSMUSP00000037328; ENSMUSG00000039131.
DR GeneID; 54120; -.
DR KEGG; mmu:54120; -.
DR UCSC; uc008rsp.1; mouse.
DR CTD; 54810; -.
DR MGI; MGI:1889209; Gipc2.
DR VEuPathDB; HostDB:ENSMUSG00000039131; -.
DR eggNOG; KOG3938; Eukaryota.
DR GeneTree; ENSGT00390000003420; -.
DR HOGENOM; CLU_044527_1_0_1; -.
DR InParanoid; Q9Z2H7; -.
DR OMA; NGVGCAF; -.
DR OrthoDB; 1442796at2759; -.
DR PhylomeDB; Q9Z2H7; -.
DR TreeFam; TF313878; -.
DR BioGRID-ORCS; 54120; 5 hits in 73 CRISPR screens.
DR ChiTaRS; Gipc2; mouse.
DR PRO; PR:Q9Z2H7; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q9Z2H7; protein.
DR Bgee; ENSMUSG00000039131; Expressed in pyloric antrum and 179 other tissues.
DR Genevisible; Q9Z2H7; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR017379; GIPC1/2/3.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR12259; PTHR12259; 1.
DR Pfam; PF00595; PDZ; 1.
DR PIRSF; PIRSF038083; UCP038083_GIPC; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome.
FT CHAIN 1..314
FT /note="PDZ domain-containing protein GIPC2"
FT /id="PRO_0000247189"
FT DOMAIN 117..197
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 89
FT /note="P -> H (in Ref. 2; BAB25591)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 314 AA; 34118 MW; C73E40AD8DFCF8FA CRC64;
MPLGLRGKKK AAKSKEAARL VEGERSSGSQ GVPGPPAPAR KLVFHAQLAH GSATGRVEDF
SSISELYAKI AGVFEIAPSE ILFCTLNTPK IDMGKLLGGQ LGLEDFIFAH VKGTKKEVNV
YKSEDSLGLT ITDNGVGYAF IKRIKDGSTI DSVKTICVGD HIECINGENI VGWRHFEVAK
KLKELKKEEL FTLQLIEPKK AFEIGPRSKA GKTSTEKIGT SRGTLRLRSK GPATVEELPS
EAKAKAIGKV DDLLELYMGI RDIDLATTMF EAGKDKSNPD EFAVALDETL GDFAFPDEFL
FDVWGAISDM KQGR
