ID   GIP_BOVIN               Reviewed;          42 AA.
AC   P09680;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Gastric inhibitory polypeptide;
DE            Short=GIP;
DE   AltName: Full=Glucose-dependent insulinotropic polypeptide;
GN   Name=GIP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=6391923; DOI=10.1111/j.1432-1033.1984.tb08595.x;
RA   Carlquist M., Maletti M., Joernvall H., Mutt V.;
RT   "A novel form of gastric inhibitory polypeptide (GIP) isolated from bovine
RT   intestine using a radioreceptor assay. Fragmentation with staphylococcal
RT   protease results in GIP1-3 and GIP4-42, fragmentation with enterokinase in
RT   GIP1-16 and GIP17-42.";
RL   Eur. J. Biochem. 145:573-577(1984).
CC   -!- FUNCTION: Potent stimulator of insulin secretion and relatively poor
CC       inhibitor of gastric acid secretion.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   PIR; S07231; GIBO.
DR   AlphaFoldDB; P09680; -.
DR   SMR; P09680; -.
DR   STRING; 9913.ENSBTAP00000006656; -.
DR   PaxDb; P09680; -.
DR   eggNOG; ENOG502S7ZH; Eukaryota.
DR   HOGENOM; CLU_146415_0_0_1; -.
DR   InParanoid; P09680; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031769; F:glucagon receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0042304; P:regulation of fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:InterPro.
DR   GO; GO:0009749; P:response to glucose; IEA:InterPro.
DR   GO; GO:0042594; P:response to starvation; IBA:GO_Central.
DR   InterPro; IPR039078; GIP.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR15211; PTHR15211; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Reference proteome; Secreted.
FT   CHAIN           1..42
FT                   /note="Gastric inhibitory polypeptide"
FT                   /id="PRO_0000148918"
SQ   SEQUENCE   42 AA;  4961 MW;  7DAE3E5C09390F9F CRC64;
     YAEGTFISDY SIAMDKIRQQ DFVNWLLAQK GKKSDWIHNI TQ