ID   GIP_PIG                 Reviewed;          42 AA.
AC   P01281;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Gastric inhibitory polypeptide;
DE            Short=GIP;
DE   AltName: Full=Glucose-dependent insulinotropic polypeptide;
GN   Name=GIP;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=7227513; DOI=10.1016/0014-5793(81)80288-8;
RA   Joernvall H., Carlquist M., Kwauk S., Otte S.C., McIntosh C.H.S.,
RA   Brown J.C., Mutt V.;
RT   "Amino acid sequence and heterogeneity of gastric inhibitory polypeptide
RT   (GIP).";
RL   FEBS Lett. 123:205-210(1981).
RN   [2]
RP   PROTEIN SEQUENCE OF 7-42.
RC   TISSUE=Intestine;
RX   PubMed=8375398; DOI=10.1111/j.1432-1033.1993.tb18182.x;
RA   Agerberth B., Boman A., Andersson M., Joernvall H., Mutt V., Boman H.G.;
RT   "Isolation of three antibacterial peptides from pig intestine: gastric
RT   inhibitory polypeptide (7-42), diazepam-binding inhibitor (32-86) and a
RT   novel factor, peptide 3910.";
RL   Eur. J. Biochem. 216:623-629(1993).
CC   -!- FUNCTION: Potent stimulator of insulin secretion and relatively poor
CC       inhibitor of gastric acid secretion.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the glucagon family. {ECO:0000305}.
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DR   PIR; A01546; GIPG.
DR   AlphaFoldDB; P01281; -.
DR   SMR; P01281; -.
DR   STRING; 9823.ENSSSCP00000023744; -.
DR   PaxDb; P01281; -.
DR   eggNOG; ENOG502S7ZH; Eukaryota.
DR   HOGENOM; CLU_146415_0_0_1; -.
DR   InParanoid; P01281; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0031769; F:glucagon receptor binding; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:BHF-UCL.
DR   GO; GO:0038192; P:gastric inhibitory peptide signaling pathway; IDA:BHF-UCL.
DR   GO; GO:0042304; P:regulation of fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0050796; P:regulation of insulin secretion; IEA:InterPro.
DR   GO; GO:0009749; P:response to glucose; IEA:InterPro.
DR   GO; GO:0042594; P:response to starvation; IBA:GO_Central.
DR   InterPro; IPR039078; GIP.
DR   InterPro; IPR000532; Glucagon_GIP_secretin_VIP.
DR   PANTHER; PTHR15211; PTHR15211; 1.
DR   Pfam; PF00123; Hormone_2; 1.
DR   SMART; SM00070; GLUCA; 1.
DR   PROSITE; PS00260; GLUCAGON; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hormone; Reference proteome; Secreted.
FT   CHAIN           1..42
FT                   /note="Gastric inhibitory polypeptide"
FT                   /id="PRO_0000148919"
FT   VARIANT         41..42
FT                   /note="Missing (in a second component)"
SQ   SEQUENCE   42 AA;  4976 MW;  7DAE3E5C093A6F9F CRC64;
     YAEGTFISDY SIAMDKIRQQ DFVNWLLAQK GKKSDWKHNI TQ