ID   GIS2_ARATH              Reviewed;         191 AA.
AC   Q9FG05;
DT   19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Zinc finger protein GIS2;
DE   AltName: Full=Protein GLABROUS INFLORESCENCE STEMS 2;
GN   Name=GIS2; OrderedLocusNames=At5g06650;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RA   Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA   Takagi M.;
RT   "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   FUNCTION, TISSUE SPECIFICITY, INDUCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=17507408; DOI=10.1242/dev.005017;
RA   Gan Y., Liu C., Yu H., Broun P.;
RT   "Integration of cytokinin and gibberellin signalling by Arabidopsis
RT   transcription factors GIS, ZFP8 and GIS2 in the regulation of epidermal
RT   cell fate.";
RL   Development 134:2073-2081(2007).
CC   -!- FUNCTION: Probable transcription factor required for the initiation of
CC       inflorescence trichomes in response to gibberellin and cytokinin. Is
CC       not involved in the regulation of trichome branching. Is functionally
CC       equivalent to ZFP8. {ECO:0000269|PubMed:17507408}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9SLB8}.
CC   -!- TISSUE SPECIFICITY: Expressed in inflorescence meristems, floral
CC       meristems and stem epidermis. {ECO:0000269|PubMed:17507408}.
CC   -!- INDUCTION: By cytokinin and gibberellin. {ECO:0000269|PubMed:17507408}.
CC   -!- DISRUPTION PHENOTYPE: Reduced trichome production on cauline leaves,
CC       stem branches and sepals. {ECO:0000269|PubMed:17507408}.
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DR   EMBL; AP002543; BAB11414.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED91046.1; -; Genomic_DNA.
DR   EMBL; AB493740; BAH30578.1; -; Genomic_DNA.
DR   RefSeq; NP_196283.1; NM_120748.2.
DR   AlphaFoldDB; Q9FG05; -.
DR   BioGRID; 15832; 15.
DR   IntAct; Q9FG05; 15.
DR   STRING; 3702.AT5G06650.1; -.
DR   PaxDb; Q9FG05; -.
DR   PRIDE; Q9FG05; -.
DR   EnsemblPlants; AT5G06650.1; AT5G06650.1; AT5G06650.
DR   GeneID; 830553; -.
DR   Gramene; AT5G06650.1; AT5G06650.1; AT5G06650.
DR   KEGG; ath:AT5G06650; -.
DR   Araport; AT5G06650; -.
DR   TAIR; locus:2144168; AT5G06650.
DR   eggNOG; ENOG502R1BM; Eukaryota.
DR   HOGENOM; CLU_058544_1_0_1; -.
DR   InParanoid; Q9FG05; -.
DR   OMA; FNLHSNA; -.
DR   OrthoDB; 1384062at2759; -.
DR   PhylomeDB; Q9FG05; -.
DR   PRO; PR:Q9FG05; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FG05; baseline and differential.
DR   Genevisible; Q9FG05; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0009736; P:cytokinin-activated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0009740; P:gibberellic acid mediated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR   GO; GO:0009735; P:response to cytokinin; IMP:TAIR.
DR   GO; GO:0009739; P:response to gibberellin; IMP:TAIR.
DR   GO; GO:0010026; P:trichome differentiation; IMP:TAIR.
DR   GO; GO:0010090; P:trichome morphogenesis; IEA:InterPro.
DR   InterPro; IPR044291; GIS/GIS2/ZFP8.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR46547; PTHR46547; 1.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   2: Evidence at transcript level;
KW   Cytokinin signaling pathway; Developmental protein; Differentiation;
KW   Gibberellin signaling pathway; Metal-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..191
FT                   /note="Zinc finger protein GIS2"
FT                   /id="PRO_0000425725"
FT   ZN_FING         55..77
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   191 AA;  22466 MW;  4676C0D56A05E267 CRC64;
     MKTYDFMNVN SFSPKERPIR LFGFEFGASH EESESKDNYN ENNESIKDDN KEKRFKCHYC
     FRNFPTSQAL GGHQNAHKRE RQQTKRFNLH SNAAAFFHRQ QNHIAASRLY EDRYSLEAVQ
     INDARLGLCR MYNSSASFNR DRSSYYNRYI PWFIGDHQTR PTYVGGGSSS HGLFYESKKN
     VPDHVSLDLR L