GIS_ARATH
ID GIS_ARATH Reviewed; 253 AA.
AC Q84WI0; Q9M2P1;
DT 19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Zinc finger protein GIS;
DE AltName: Full=Protein GLABROUS INFLORESCENCE STEMS;
GN Name=GIS; OrderedLocusNames=At3g58070; ORFNames=T10K17.280;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP FUNCTION, TISSUE SPECIFICITY, INDUCTION BY GIBBERELLIN, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=16679458; DOI=10.1105/tpc.106.041533;
RA Gan Y., Kumimoto R., Liu C., Ratcliffe O., Yu H., Broun P.;
RT "GLABROUS INFLORESCENCE STEMS modulates the regulation by gibberellins of
RT epidermal differentiation and shoot maturation in Arabidopsis.";
RL Plant Cell 18:1383-1395(2006).
RN [5]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=17507408; DOI=10.1242/dev.005017;
RA Gan Y., Liu C., Yu H., Broun P.;
RT "Integration of cytokinin and gibberellin signalling by Arabidopsis
RT transcription factors GIS, ZFP8 and GIS2 in the regulation of epidermal
RT cell fate.";
RL Development 134:2073-2081(2007).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22210898; DOI=10.1093/pcp/pcr192;
RA An L., Zhou Z., Su S., Yan A., Gan Y.;
RT "GLABROUS INFLORESCENCE STEMS (GIS) is required for trichome branching
RT through gibberellic acid signaling in Arabidopsis.";
RL Plant Cell Physiol. 53:457-469(2012).
RN [7]
RP FUNCTION.
RX PubMed=23825141; DOI=10.1631/jzus.b1200349;
RA Sun L.L., Zhou Z.J., An L.J., An Y., Zhao Y.Q., Meng X.F., Steele-King C.,
RA Gan Y.B.;
RT "GLABROUS INFLORESCENCE STEMS regulates trichome branching by genetically
RT interacting with SIM in Arabidopsis.";
RL J. Zhejiang Univ. Sci. B 14:563-569(2013).
CC -!- FUNCTION: Probable transcription factor required for the initiation of
CC inflorescence trichomes in response to gibberellin (GA)
CC (PubMed:16679458, PubMed:17507408). Mediates the induction of GL1
CC expression by GA in inflorescence organs and is antagonized in its
CC action by the DELLA repressor GAI. Acts upstream of the trichome
CC initiation regulators GL1 and GL3, and downstream of the GA signaling
CC repressor SPINDLY (SPY) (PubMed:16679458). Does not play a significant
CC role in the cytokinin response (PubMed:17507408). Controls trichome
CC branching through GA signaling (PubMed:22210898, PubMed:23825141). Acts
CC downstream of the key regulator STICHEL (STI) in an endoreduplication-
CC independent pathway (PubMed:22210898). Controls trichome cell division
CC indirectly by acting downstream of a key endoreduplication regulator
CC SIAMESE (SIM) (PubMed:23825141). {ECO:0000269|PubMed:16679458,
CC ECO:0000269|PubMed:17507408, ECO:0000269|PubMed:22210898,
CC ECO:0000269|PubMed:23825141}.
CC -!- INTERACTION:
CC Q84WI0; O82239: RFI2; NbExp=3; IntAct=EBI-15195983, EBI-4425094;
CC Q84WI0; Q8LPR5: TCP4; NbExp=3; IntAct=EBI-15195983, EBI-15192325;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9SLB8}.
CC -!- TISSUE SPECIFICITY: Expressed in inflorescence meristems, floral
CC meristems and stem epidermis. {ECO:0000269|PubMed:16679458}.
CC -!- INDUCTION: By gibberellin. {ECO:0000269|PubMed:16679458}.
CC -!- DISRUPTION PHENOTYPE: Reduced trichome production on cauline leaves,
CC stem internodes and branches, and sepals. {ECO:0000269|PubMed:16679458,
CC ECO:0000269|PubMed:17507408, ECO:0000269|PubMed:22210898}.
CC -!- MISCELLANEOUS: Plants over-expressing GIS have delayed shoot maturation
CC and flowering, and a strong production of trichome on the
CC inflorescence. {ECO:0000305|PubMed:16679458}.
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DR EMBL; AL132977; CAB67635.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79738.1; -; Genomic_DNA.
DR EMBL; BT003340; AAO29959.1; -; mRNA.
DR EMBL; BT009676; AAP80177.1; -; mRNA.
DR PIR; T46029; T46029.
DR RefSeq; NP_191366.1; NM_115669.3.
DR AlphaFoldDB; Q84WI0; -.
DR BioGRID; 10291; 15.
DR IntAct; Q84WI0; 15.
DR STRING; 3702.AT3G58070.1; -.
DR PaxDb; Q84WI0; -.
DR PRIDE; Q84WI0; -.
DR ProteomicsDB; 220769; -.
DR EnsemblPlants; AT3G58070.1; AT3G58070.1; AT3G58070.
DR GeneID; 824976; -.
DR Gramene; AT3G58070.1; AT3G58070.1; AT3G58070.
DR KEGG; ath:AT3G58070; -.
DR Araport; AT3G58070; -.
DR TAIR; locus:2095883; AT3G58070.
DR eggNOG; ENOG502R1BM; Eukaryota.
DR HOGENOM; CLU_058544_1_0_1; -.
DR InParanoid; Q84WI0; -.
DR OMA; FYRSHFR; -.
DR OrthoDB; 1384062at2759; -.
DR PhylomeDB; Q84WI0; -.
DR PRO; PR:Q84WI0; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q84WI0; baseline and differential.
DR Genevisible; Q84WI0; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0009740; P:gibberellic acid mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR GO; GO:0009739; P:response to gibberellin; IMP:TAIR.
DR GO; GO:0010091; P:trichome branching; IMP:TAIR.
DR GO; GO:0010026; P:trichome differentiation; IMP:TAIR.
DR InterPro; IPR044291; GIS/GIS2/ZFP8.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR46547; PTHR46547; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Gibberellin signaling pathway;
KW Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..253
FT /note="Zinc finger protein GIS"
FT /id="PRO_0000425724"
FT ZN_FING 91..113
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 169
FT /note="T -> S (in Ref. 1; CAB67635)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 253 AA; 28457 MW; 27F1DE2F16D6F30F CRC64;
MDEATGETET QDFMNVESFS QLPFIRRPKD KNPKPIRVFG KDFTGRDFSI TTGQEDYTDP
YQTKNKEEEE EEDQTGDNST DNNSISHNRR FECHYCFRNF PTSQALGGHQ NAHKRERQLA
KRGVSSYFYH PDNNPYSYRH YPSWTNGPLT AARSYGGFSS GPKPSGYYTR PSYGSQLGLW
RLPPRVQGVY NSNAAFTSNG SSSSSNSTLP LLTRSQTQLS SQVGGSAAQN RMSSYGYGLS
PNVQDHVSLD LHL