ID   GIT2_CANAL              Reviewed;         534 AA.
AC   A0A1D8PN12;
DT   10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT   18-JAN-2017, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Glycerophosphodiester transporter GIT2 {ECO:0000305|PubMed:24114876};
GN   Name=GIT2 {ECO:0000303|PubMed:24114876};
GN   OrderedLocusNames=CAALFM_C500890CA;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN   [4]
RP   FUNCTION, DISRUPTION PHENOTYPE, AND INDUCTION.
RX   PubMed=24114876; DOI=10.1074/jbc.m113.505735;
RA   Bishop A.C., Ganguly S., Solis N.V., Cooley B.M., Jensen-Seaman M.I.,
RA   Filler S.G., Mitchell A.P., Patton-Vogt J.;
RT   "Glycerophosphocholine utilization by Candida albicans: role of the Git3
RT   transporter in virulence.";
RL   J. Biol. Chem. 288:33939-33952(2013).
CC   -!- FUNCTION: Probable glycerophosphodiester transporter (PubMed:24114876).
CC       Does not possess detectable glycerophosphoinositol (GroPIns) transport
CC       activity (PubMed:24114876). Might be involved in the uptake of
CC       glycerophosphocholine (GroPCho) (PubMed:24114876). The expanded ability
CC       to utilize GroPIns and GroPCho results from the organism's pathogenic
CC       nature and its need to occupy a variety of environments within its host
CC       organism (PubMed:24114876). This possibility is buttressed by the fact
CC       that GroPIns and GroPCho are present and abundant in human fluids
CC       (PubMed:24114876). {ECO:0000269|PubMed:24114876}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: In contrast to the other glycerophosphodiester transporters,
CC       expression is largely unresponsive to phosphate levels
CC       (PubMed:24114876). {ECO:0000269|PubMed:24114876}.
CC   -!- DISRUPTION PHENOTYPE: Triple deletion of GIT2, GIT3 and GIT4 impairs
CC       the uptake of glycerophosphocholine (GroPCho) and reduces virulence in
CC       a mouse model of blood stream infection (PubMed:24114876).
CC       {ECO:0000269|PubMed:24114876}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC       transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR   EMBL; CP017627; AOW29531.1; -; Genomic_DNA.
DR   RefSeq; XP_715740.2; XM_710647.2.
DR   AlphaFoldDB; A0A1D8PN12; -.
DR   SMR; A0A1D8PN12; -.
DR   STRING; 237561.A0A1D8PN12; -.
DR   GeneID; 3642633; -.
DR   KEGG; cal:CAALFM_C500890CA; -.
DR   CGD; CAL0000177809; GIT2.
DR   VEuPathDB; FungiDB:C5_00890C_A; -.
DR   eggNOG; KOG0252; Eukaryota.
DR   OMA; WIFPAIQ; -.
DR   OrthoDB; 419975at2759; -.
DR   Proteomes; UP000000559; Chromosome 5.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR005828; MFS_sugar_transport-like.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF00083; Sugar_tr; 2.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..534
FT                   /note="Glycerophosphodiester transporter GIT2"
FT                   /id="PRO_0000439799"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        322..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        350..370
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        453..473
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   534 AA;  59304 MW;  1FED87D4133393C3 CRC64;
     MASRDLPHSL NDLAFGWIKH LKEEIIINKN SQQLVDEDFQ PDEDVTKETK VKLNNLWPAF
     ASGAGLFADG YVNNSIGIVM ACLKILYGDE FTKSNAISNI GSIGFVGTVV GQLSFGYISD
     RVARKGGMMT ANIMLIAFTL LCAVGSWGTT IQGFFACLTV WRFCLGVAIG AEYPTSSVIA
     SEFANQLPAG KRNRYFIWFT GFMIDFGFVV SAFVPFVLLW IFTEKHLRAL WRVSIGLGAI
     LPTALFFIRL KMKDSTSFEK LHMKNVRYRD YPWWLIVKFY WFRLTIVSMI WFIYNFSVYS
     FGTFNAIILG QIIPDAPLWQ QWGWSVVFNL FYIPGSFLGA FSADYLGPRL TLAIGVGLQG
     IIGFIMSACL NGLRKQVAAF TVVFGIFATL GEFGPGGNIG LLASKTSATP IRGQYYGIAA
     AMGKIGAFVG TWIFPAIQRR YASKTNPDLE LQVPFYLSSG LCIFSALLTF FLCPHVGQDA
     INREDKEFVE YLRKNGFDVS KLGEDSSSVD VDVVKDTDSA EKISETIEVG QKLA