GIT3_SCHPO
ID GIT3_SCHPO Reviewed; 466 AA.
AC O94744;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 122.
DE RecName: Full=Glucose receptor protein git3;
DE AltName: Full=Glucose-insensitive transcription protein 3;
GN Name=git3; ORFNames=SPCC1753.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=11014802; DOI=10.1093/genetics/156.2.513;
RA Welton R.M., Hoffman C.S.;
RT "Glucose monitoring in fission yeast via the gpa2 Galpha, the git5 Gbeta
RT and the git3 putative glucose receptor.";
RL Genetics 156:513-521(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Activates gpa2 when triggered by glucose and then activates
CC adenylate cyclase. {ECO:0000269|PubMed:11014802}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor GPR1/git3 family.
CC {ECO:0000305}.
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DR EMBL; CU329672; CAA22776.1; -; Genomic_DNA.
DR EMBL; AF085162; AAC69337.1; -; Genomic_DNA.
DR PIR; T41125; T41125.
DR RefSeq; NP_588228.1; NM_001023218.2.
DR AlphaFoldDB; O94744; -.
DR SMR; O94744; -.
DR BioGRID; 275353; 82.
DR STRING; 4896.SPCC1753.02c.1; -.
DR PaxDb; O94744; -.
DR EnsemblFungi; SPCC1753.02c.1; SPCC1753.02c.1:pep; SPCC1753.02c.
DR GeneID; 2538770; -.
DR KEGG; spo:SPCC1753.02c; -.
DR PomBase; SPCC1753.02c; git3.
DR VEuPathDB; FungiDB:SPCC1753.02c; -.
DR eggNOG; ENOG502QU8E; Eukaryota.
DR HOGENOM; CLU_586832_0_0_1; -.
DR InParanoid; O94744; -.
DR OMA; ALYIFRP; -.
DR PhylomeDB; O94744; -.
DR PRO; PR:O94744; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:1990576; F:G protein-coupled glucose receptor activity; IGI:PomBase.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0010619; P:adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway; IMP:PomBase.
DR GO; GO:0010515; P:negative regulation of induction of conjugation with cellular fusion; IMP:PomBase.
DR InterPro; IPR023041; Glucose_rcpt_Git3_N.
DR Pfam; PF11710; Git3; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Membrane; Receptor; Reference proteome;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..466
FT /note="Glucose receptor protein git3"
FT /id="PRO_0000195085"
FT TRANSMEM 30..50
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 144..164
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT REGION 262..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 262..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..337
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 466 AA; 53860 MW; 86676D2E5CEF6A7A CRC64;
MLHLDYTFNV SDATSTSSII IVSRRELANL RIMVIIASAI SIVFSLIAIF WRWSRRRTIR
EQFHIALFSV LFIRSIVQMI HPCLALSDPF FWAPKHRCFT IGFFLLVLVR MTDYWIFINI
LHNALLVLFP HVDTERRGLY RFRHTVFTLS FVIPLTIGGL AFTNKRNTFV NLQTRCYLPY
TPVRFMFGLN WSFDYALSIA IIALQTCMFI SIRRKIKRFK KYSHQQTNVF DTLNVIDSYP
TAPDQVALPP FPDTNSTLTY TPSNSQSIYS SQSQPSPYSR PLLSSVHPNL PPGSQSTPAN
LNQSGIHFEQ DFRDSPNRTN GLEDHTSFKL SSPLTSDEDG ASSVLAAYGN DMQDDPLLKQ
RKRILSQSKF LFAYPAIFIF MWILPQIQII VILAQPLHCS GSCKRFAFVA VFADNFVAIF
IALSDFIWIC YRGYTYLKER DSSKSYWDQI KELTLKWWRG KFGEEK
