GIT7_SCHPO
ID GIT7_SCHPO Reviewed; 379 AA.
AC O59709; Q9C1X3;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Glucose-insensitive transcription protein 7;
GN Name=git7; ORFNames=SPBC36.12c, SPBC713.01c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=12456004; DOI=10.1128/ec.1.4.558-567.2002;
RA Schadick K., Fourcade H.M., Boumenot P., Seitz J.J., Morrell J.L.,
RA Chang L., Gould K.L., Partridge J.F., Allshire R.C., Kitagawa K.,
RA Hieter P., Hoffman C.S.;
RT "Schizosaccharomyces pombe Git7p, a member of the Saccharomyces cerevisiae
RT Sgtlp family, is required for glucose and cyclic AMP signaling, cell wall
RT integrity, and septation.";
RL Eukaryot. Cell 1:558-567(2002).
CC -!- FUNCTION: Involved in cyclic AMP (cAMP) pathway, possibly by
CC participating in the assembly or the conformational activation of
CC specific multiprotein complexes. {ECO:0000269|PubMed:12456004}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329671; CAA19060.2; -; Genomic_DNA.
DR PIR; T40307; T40307.
DR RefSeq; NP_595340.1; NM_001021248.2.
DR AlphaFoldDB; O59709; -.
DR SMR; O59709; -.
DR BioGRID; 277478; 4.
DR STRING; 4896.SPBC36.12c.1; -.
DR MaxQB; O59709; -.
DR PaxDb; O59709; -.
DR PRIDE; O59709; -.
DR EnsemblFungi; SPBC36.12c.1; SPBC36.12c.1:pep; SPBC36.12c.
DR GeneID; 2540962; -.
DR KEGG; spo:SPBC36.12c; -.
DR PomBase; SPBC36.12c; git7.
DR VEuPathDB; FungiDB:SPBC36.12c; -.
DR eggNOG; KOG1309; Eukaryota.
DR HOGENOM; CLU_039532_3_1_1; -.
DR InParanoid; O59709; -.
DR OMA; WRTWINE; -.
DR PhylomeDB; O59709; -.
DR Reactome; R-SPO-844456; The NLRP3 inflammasome.
DR PRO; PR:O59709; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0051087; F:chaperone binding; ISO:PomBase.
DR GO; GO:0010619; P:adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway; IMP:PomBase.
DR GO; GO:0006457; P:protein folding; IC:PomBase.
DR GO; GO:0050821; P:protein stabilization; IBA:GO_Central.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR007699; SGS_dom.
DR InterPro; IPR044563; Sgt1-like.
DR PANTHER; PTHR45862; PTHR45862; 1.
DR Pfam; PF04969; CS; 1.
DR Pfam; PF05002; SGS; 1.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS51203; CS; 1.
DR PROSITE; PS51048; SGS; 1.
PE 4: Predicted;
KW Reference proteome.
FT CHAIN 1..379
FT /note="Glucose-insensitive transcription protein 7"
FT /id="PRO_0000185392"
FT DOMAIN 181..272
FT /note="CS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00547"
FT DOMAIN 292..379
FT /note="SGS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00386"
FT REGION 345..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 379 AA; 42962 MW; 157AD88B79374EAC CRC64;
MGVDLSDIND SLFKLSDKLS NDLAKQRNLC IVKEPSFSIE EHIKCFTTCI NTYKPFSCLK
HANWALLLAK KKSDTGLIGY CQSLRGLAYY LLEQYQSSAI CFGFALKHLK KEDLTKWQVQ
LDSMLTIVHE QQNQDTSSLI PDECPNIPEL EAAKIEGDEE FLNMSLKAPE GQIEKNEEKL
SNRIRYDWSQ TSFSLNIDIY AKKVKDEDVS LLMEKNTLKI EIKLEDGSIF SLVLDPLYEE
IVPEKSSFKL FSSKVEITLI KKVSEIKWEA LVKSPANNSV NVYAKDSNHS SASGNTKNKA
KDWDSLAKLA DLEEDEPTGE AALANLFQNL YKNADDDTRR AMMKSYTESN GTALSTNWKD
VKSKTFETKP PQGMEPKKF
