GJ_HHV11
ID GJ_HHV11 Reviewed; 92 AA.
AC P06480; Q771F7;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1988, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Envelope glycoprotein J;
DE Flags: Precursor;
GN Name=gJ; ORFNames=US5;
OS Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX NCBI_TaxID=10299;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2984429; DOI=10.1016/0022-2836(85)90320-1;
RA McGeoch D.J., Dolan A., Donald S., Rixon F.J.;
RT "Sequence determination and genetic content of the short unique region in
RT the genome of herpes simplex virus type 1.";
RL J. Mol. Biol. 181:1-13(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=2839594; DOI=10.1099/0022-1317-69-7-1531;
RA McGeoch D.J., Dalrymple M.A., Davison A.J., Dolan A., Frame M.C., McNab D.,
RA Perry L.J., Scott J.E., Taylor P.;
RT "The complete DNA sequence of the long unique region in the genome of
RT herpes simplex virus type 1.";
RL J. Gen. Virol. 69:1531-1574(1988).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate P01, Isolate P02, Isolate P06, Isolate P10, Isolate P12,
RC Isolate P13, Isolate SG007, Isolate SG009, Isolate SG010, Isolate SK005,
RC Isolate SK007, Isolate SK008, Isolate SK012, Isolate SK013, Isolate SK015,
RC Isolate SK019, Isolate SK020, Isolate SK024, Isolate SK025, Isolate SK081,
RC Isolate SK095, Isolate SK096, Isolate SK097, SK006, and SK027;
RA Bowden R.J.;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Isolate P01, Isolate P02, Isolate P06, Isolate P10, Isolate P12,
RC Isolate P13, Isolate SG007, Isolate SG009, Isolate SG010, Isolate SK005,
RC Isolate SK006, Isolate SK007, Isolate SK008, Isolate SK012, Isolate SK013,
RC Isolate SK015, Isolate SK019, Isolate SK020, Isolate SK024, Isolate SK025,
RC Isolate SK027, Isolate SK081, Isolate SK095, Isolate SK096, and
RC Isolate SK097;
RX PubMed=16376841; DOI=10.1016/j.meegid.2005.01.004;
RA Bowden R., Sakaoka H., Ward R., Donnelly P.;
RT "Patterns of Eurasian HSV-1 molecular diversity and inferences of human
RT migrations.";
RL Infect. Genet. Evol. 6:63-74(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nonneuroinvasive mutant HF10;
RX PubMed=17218138; DOI=10.1016/j.micinf.2006.10.019;
RA Ushijima Y., Luo C., Goshima F., Yamauchi Y., Kimura H., Nishiyama Y.;
RT "Determination and analysis of the DNA sequence of highly attenuated herpes
RT simplex virus type 1 mutant HF10, a potential oncolytic virus.";
RL Microbes Infect. 9:142-149(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17 syn+;
RA Cunningham C., Davison A.J.;
RT "Herpes simplex virus type 1 bacterial artificial chromosome.";
RL Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RC STRAIN=F;
RX PubMed=17959661; DOI=10.1128/jvi.01341-07;
RA Aubert M., Chen Z., Lang R., Dang C.H., Fowler C., Sloan D.D., Jerome K.R.;
RT "The antiapoptotic herpes simplex virus glycoprotein J localizes to
RT multiple cellular organelles and induces reactive oxygen species
RT formation.";
RL J. Virol. 82:617-629(2008).
RN [8]
RP SUBCELLULAR LOCATION.
RC STRAIN=F;
RX PubMed=18596102; DOI=10.1128/jvi.00904-08;
RA Loret S., Guay G., Lippe R.;
RT "Comprehensive characterization of extracellular herpes simplex virus type
RT 1 virions.";
RL J. Virol. 82:8605-8618(2008).
CC -!- FUNCTION: Inhibits host cell apoptosis. Induces an increase in reactive
CC oxygen species (ROS) in the host cell. {ECO:0000269|PubMed:17959661}.
CC -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane {ECO:0000305};
CC Single-pass type I membrane protein {ECO:0000305}. Host endoplasmic
CC reticulum membrane {ECO:0000305}; Single-pass type I membrane protein
CC {ECO:0000305}. Host endosome membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the alphaherpesvirinae glycoprotein J family.
CC {ECO:0000305}.
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DR EMBL; L00036; AAA96683.1; -; Genomic_DNA.
DR EMBL; X14112; CAA32282.1; -; Genomic_DNA.
DR EMBL; X02138; CAA26059.1; -; Genomic_DNA.
DR EMBL; AY240646; AAP39247.1; -; Genomic_DNA.
DR EMBL; AY240647; AAP39250.1; -; Genomic_DNA.
DR EMBL; AY240651; AAP39262.1; -; Genomic_DNA.
DR EMBL; AY240655; AAP39274.1; -; Genomic_DNA.
DR EMBL; AY240657; AAP39280.1; -; Genomic_DNA.
DR EMBL; AY240658; AAP39283.1; -; Genomic_DNA.
DR EMBL; AY240789; AAP39676.1; -; Genomic_DNA.
DR EMBL; AY240790; AAP39679.1; -; Genomic_DNA.
DR EMBL; AY240791; AAP39682.1; -; Genomic_DNA.
DR EMBL; AY240794; AAP39691.1; -; Genomic_DNA.
DR EMBL; AY240795; AAP39694.1; -; Genomic_DNA.
DR EMBL; AY240796; AAP39697.1; -; Genomic_DNA.
DR EMBL; AY240797; AAP39700.1; -; Genomic_DNA.
DR EMBL; AY240800; AAP39709.1; -; Genomic_DNA.
DR EMBL; AY240801; AAP39712.1; -; Genomic_DNA.
DR EMBL; AY240802; AAP39715.1; -; Genomic_DNA.
DR EMBL; AY240805; AAP39724.1; -; Genomic_DNA.
DR EMBL; AY240806; AAP39727.1; -; Genomic_DNA.
DR EMBL; AY240808; AAP39733.1; -; Genomic_DNA.
DR EMBL; AY240809; AAP39736.1; -; Genomic_DNA.
DR EMBL; AY240811; AAP39742.1; -; Genomic_DNA.
DR EMBL; AY240812; AAP39745.1; -; Genomic_DNA.
DR EMBL; AY240820; AAP39769.1; -; Genomic_DNA.
DR EMBL; AY240821; AAP39772.1; -; Genomic_DNA.
DR EMBL; AY240822; AAP39775.1; -; Genomic_DNA.
DR EMBL; DQ889502; ABI63523.1; -; Genomic_DNA.
DR EMBL; FJ593289; ACM62294.1; -; Genomic_DNA.
DR PIR; A05240; QQBE75.
DR RefSeq; YP_009137140.1; NC_001806.2.
DR ChEMBL; CHEMBL2364696; -.
DR DrugCentral; P06480; -.
DR DNASU; 2703406; -.
DR GeneID; 2703406; -.
DR KEGG; vg:2703406; -.
DR PRO; PR:P06480; -.
DR Proteomes; UP000009294; Genome.
DR Proteomes; UP000180652; Genome.
DR GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR004913; Herpes_gJ.
DR Pfam; PF03229; Alpha_GJ; 1.
PE 3: Inferred from homology;
KW Glycoprotein; Host endoplasmic reticulum; Host endosome;
KW Host Golgi apparatus; Host membrane; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..92
FT /note="Envelope glycoprotein J"
FT /id="PRO_0000115789"
FT TOPO_DOM 22..49
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..92
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 30
FT /note="N-linked (GlcNAc...) asparagine; by host"
FT /evidence="ECO:0000255"
SQ SEQUENCE 92 AA; 9556 MW; 14DA8BD9F18DA655 CRC64;
MSLRAVWHLG LLGSLVGAVL AATHRGPAAN TTDPLTHAPV SPHPSPLGGF AVPLVVGGLC
AVVLGAACLL ELLRRTCRGW GRYHPYMDPV VV
