ID   GJ_HHV2H                Reviewed;          92 AA.
AC   P13293;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   23-FEB-2022, entry version 65.
DE   RecName: Full=Envelope glycoprotein J;
DE   Flags: Precursor;
GN   Name=gJ; ORFNames=US5;
OS   Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10315;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3027242; DOI=10.1099/0022-1317-68-1-19;
RA   McGeoch D.J., Moss H.W.M., McNab D., Frame M.C.;
RT   "DNA sequence and genetic content of the HindIII l region in the short
RT   unique component of the herpes simplex virus type 2 genome: identification
RT   of the gene encoding glycoprotein G, and evolutionary comparisons.";
RL   J. Gen. Virol. 68:19-38(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9499055; DOI=10.1128/jvi.72.3.2010-2021.1998;
RA   Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.;
RT   "The genome sequence of herpes simplex virus type 2.";
RL   J. Virol. 72:2010-2021(1998).
RN   [3]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=30248525; DOI=10.1016/j.virol.2018.09.004;
RA   Liu Y., Guan X., Li C., Ni F., Luo S., Wang J., Zhang D., Zhang M., Hu Q.;
RT   "HSV-2 glycoprotein J promotes viral protein expression and virus spread.";
RL   Virology 525:83-95(2018).
CC   -!- FUNCTION: Functions as an activator of viral protein expression and
CC       virus production. In turn, promotes cell-to-cell spread as well as
CC       syncytia formation. {ECO:0000269|PubMed:30248525}.
CC   -!- SUBCELLULAR LOCATION: Host Golgi apparatus membrane {ECO:0000305};
CC       Single-pass type I membrane protein {ECO:0000305}. Host endoplasmic
CC       reticulum membrane {ECO:0000305}; Single-pass type I membrane protein
CC       {ECO:0000305}. Host endosome membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}. Note=Localizes to the endoplasmic
CC       reticulum, trans-Golgi network, and early endosomes. {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Knockout mutant significantly impairs plaque and
CC       syncytia formation and decreases virus production.
CC       {ECO:0000269|PubMed:30248525}.
CC   -!- SIMILARITY: Belongs to the alphaherpesvirinae glycoprotein J family.
CC       {ECO:0000305}.
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DR   EMBL; X04798; CAA28491.1; -; Genomic_DNA.
DR   EMBL; Z86099; CAB06712.1; -; Genomic_DNA.
DR   PIR; D43674; D43674.
DR   RefSeq; YP_009137217.1; NC_001798.2.
DR   SMR; P13293; -.
DR   PRIDE; P13293; -.
DR   DNASU; 1487357; -.
DR   GeneID; 1487357; -.
DR   KEGG; vg:1487357; -.
DR   Proteomes; UP000001874; Genome.
DR   GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Glycoprotein; Host endoplasmic reticulum; Host endosome;
KW   Host Golgi apparatus; Host membrane; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..92
FT                   /note="Envelope glycoprotein J"
FT                   /id="PRO_0000115790"
FT   TOPO_DOM        23..49
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        71..92
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        33
FT                   /note="N-linked (GlcNAc...) asparagine; by host"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   92 AA;  9510 MW;  3314C6D50DF0EB83 CRC64;
     MDRYAVRTWG IVGILGCAAV GAAPTGPASD TTNATARLPT HPPLIRSGGF AVPLIVGGLC
     LMILGMACLL EVLRRLGREL ARCCPHAGQF AP