GKN1_MOUSE
ID GKN1_MOUSE Reviewed; 184 AA.
AC Q9CR36; Q9CTZ5; Q9D7K7;
DT 16-NOV-2001, integrated into UniProtKB/Swiss-Prot.
DT 29-SEP-2021, sequence version 3.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=Gastrokine-1;
DE AltName: Full=18 kDa antrum mucosa protein;
DE Short=AMP-18;
DE AltName: Full=Protein CA11 homolog;
DE Flags: Precursor;
GN Name=Gkn1; Synonyms=Amp18, Ca11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RC STRAIN=129/SvJ;
RX PubMed=12851218; DOI=10.1152/ajpgi.00453.2002;
RA Martin T.E., Powell C.T., Wang Z., Bhattacharyya S., Walsh-Reitz M.M.,
RA Agarwal K., Toback F.G.;
RT "A novel mitogenic protein that is highly expressed in cells of the gastric
RT antrum mucosa.";
RL Am. J. Physiol. 285:G332-G343(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Stomach, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=15221938; DOI=10.1002/path.1583;
RA Oien K.A., McGregor F., Butler S., Ferrier R.K., Downie I., Bryce S.,
RA Burns S., Keith W.N.;
RT "Gastrokine 1 is abundantly and specifically expressed in superficial
RT gastric epithelium, down-regulated in gastric carcinoma, and shows high
RT evolutionary conservation.";
RL J. Pathol. 203:789-797(2004).
CC -!- FUNCTION: Has mitogenic activity and may be involved in maintaining the
CC integrity of the gastric mucosal epithelium.
CC {ECO:0000269|PubMed:12851218}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12851218}.
CC Cytoplasmic granule {ECO:0000250|UniProtKB:Q9NS71}. Golgi apparatus
CC {ECO:0000250|UniProtKB:Q9NS71}. Note=Shows abundant granular
CC cytoplasmic staining, with perinuclear accentuation suggestive of the
CC Golgi apparatus. {ECO:0000250|UniProtKB:Q9NS71}.
CC -!- TISSUE SPECIFICITY: Expressed in the stomach (PubMed:15221938). Highly
CC expressed specifically in surface cells of the antrum mucosa from where
CC it is secreted. {ECO:0000269|PubMed:12851218,
CC ECO:0000269|PubMed:15221938}.
CC -!- SIMILARITY: Belongs to the gastrokine family. {ECO:0000305}.
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DR EMBL; AY139183; AAN75448.1; -; Genomic_DNA.
DR EMBL; AK008622; BAB25784.1; -; mRNA.
DR EMBL; AK008641; BAB25801.1; -; mRNA.
DR EMBL; AK008647; BAB25805.1; -; mRNA.
DR EMBL; AK008722; BAB25856.1; -; mRNA.
DR EMBL; AK008745; BAB25872.1; -; mRNA.
DR EMBL; AK008933; BAB25975.1; -; mRNA.
DR EMBL; AK008956; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK008990; BAB26010.1; -; mRNA.
DR EMBL; AK009145; BAB26103.1; -; mRNA.
DR EMBL; AK019050; BAB31525.3; -; mRNA.
DR CCDS; CCDS20319.1; -.
DR RefSeq; NP_079742.1; NM_025466.1.
DR AlphaFoldDB; Q9CR36; -.
DR STRING; 10090.ENSMUSP00000032129; -.
DR PhosphoSitePlus; Q9CR36; -.
DR MaxQB; Q9CR36; -.
DR PaxDb; Q9CR36; -.
DR PRIDE; Q9CR36; -.
DR ProteomicsDB; 268881; -.
DR Ensembl; ENSMUST00000032129; ENSMUSP00000032129; ENSMUSG00000030050.
DR GeneID; 66283; -.
DR KEGG; mmu:66283; -.
DR UCSC; uc009cth.1; mouse.
DR CTD; 56287; -.
DR MGI; MGI:1913533; Gkn1.
DR eggNOG; ENOG502S4AB; Eukaryota.
DR GeneTree; ENSGT00930000150969; -.
DR InParanoid; Q9CR36; -.
DR OrthoDB; 1464387at2759; -.
DR PhylomeDB; Q9CR36; -.
DR BioGRID-ORCS; 66283; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Gkn1; mouse.
DR PRO; PR:Q9CR36; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9CR36; protein.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0030141; C:secretory granule; IDA:MGI.
DR GO; GO:0008083; F:growth factor activity; IDA:MGI.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:MGI.
DR GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR InterPro; IPR007084; BRICHOS_dom.
DR Pfam; PF04089; BRICHOS; 1.
DR SMART; SM01039; BRICHOS; 1.
DR PROSITE; PS50869; BRICHOS; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Golgi apparatus; Mitogen; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..184
FT /note="Gastrokine-1"
FT /id="PRO_0000021333"
FT DOMAIN 54..148
FT /note="BRICHOS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00255"
FT DISULFID 81..140
FT /evidence="ECO:0000250"
FT CONFLICT 113
FT /note="P -> L (in Ref. 2; BAB26103)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 184 AA; 20134 MW; 288982F0404FFA8B CRC64;
MKLTMFVVGL LGLLAAPGFA YTVNINGNDG NVDGSGQQSV SINGVHNVAN IDNNNGWDSW
NSLWDYENSF AATRLFSKKS CIVHRMNKDA MPSLQDLDTM VKEQKGKGPG GAPPKDLMYS
VNPTRVEDLN TFGPKIAGMC RGIPTYVAEE IPGPNQPLYS KKCYTADILW ILRMSFCGTS
VETY
