GKN1_PIG
ID GKN1_PIG Reviewed; 185 AA.
AC Q8HYA9;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 29-SEP-2021, sequence version 3.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Gastrokine-1;
DE AltName: Full=18 kDa antrum mucosa protein;
DE Short=AMP-18;
DE Flags: Precursor;
GN Name=GKN1; Synonyms=AMP18;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000305};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF N-TERMINUS, FUNCTION, AND
RP TISSUE SPECIFICITY.
RX PubMed=12851218; DOI=10.1152/ajpgi.00453.2002;
RA Martin T.E., Powell C.T., Wang Z., Bhattacharyya S., Walsh-Reitz M.M.,
RA Agarwal K., Toback F.G.;
RT "A novel mitogenic protein that is highly expressed in cells of the gastric
RT antrum mucosa.";
RL Am. J. Physiol. 285:G332-G343(2003).
CC -!- FUNCTION: Has mitogenic activity and may be involved in maintaining the
CC integrity of the gastric mucosal epithelium.
CC {ECO:0000269|PubMed:12851218, ECO:0000303|PubMed:12851218}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9CR36}.
CC Cytoplasmic granule {ECO:0000250|UniProtKB:Q9NS71}. Golgi apparatus
CC {ECO:0000250|UniProtKB:Q9NS71}. Note=Shows abundant granular
CC cytoplasmic staining, with perinuclear accentuation suggestive of the
CC Golgi apparatus. {ECO:0000250|UniProtKB:Q9NS71}.
CC -!- TISSUE SPECIFICITY: Highly expressed specifically in surface cells of
CC the antrum mucosa from where it is secreted.
CC {ECO:0000269|PubMed:12851218}.
CC -!- SIMILARITY: Belongs to the gastrokine family. {ECO:0000305}.
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DR EMBL; AY139185; AAN75450.1; -; mRNA.
DR RefSeq; NP_001182708.1; NM_001195779.1.
DR RefSeq; XP_003481245.2; XM_003481197.3.
DR AlphaFoldDB; Q8HYA9; -.
DR SMR; Q8HYA9; -.
DR STRING; 9823.ENSSSCP00000021568; -.
DR PaxDb; Q8HYA9; -.
DR Ensembl; ENSSSCT00015086283; ENSSSCP00015035083; ENSSSCG00015064440.
DR Ensembl; ENSSSCT00025053252; ENSSSCP00025022673; ENSSSCG00025039204.
DR Ensembl; ENSSSCT00030044818; ENSSSCP00030020138; ENSSSCG00030032415.
DR Ensembl; ENSSSCT00035082356; ENSSSCP00035034154; ENSSSCG00035061301.
DR Ensembl; ENSSSCT00040022153; ENSSSCP00040009274; ENSSSCG00040016461.
DR Ensembl; ENSSSCT00050051879; ENSSSCP00050021788; ENSSSCG00050038456.
DR Ensembl; ENSSSCT00055029418; ENSSSCP00055023419; ENSSSCG00055014920.
DR Ensembl; ENSSSCT00060041674; ENSSSCP00060017701; ENSSSCG00060030827.
DR Ensembl; ENSSSCT00065022377; ENSSSCP00065009075; ENSSSCG00065016859.
DR GeneID; 100502561; -.
DR KEGG; ssc:100502561; -.
DR CTD; 56287; -.
DR eggNOG; ENOG502S4AB; Eukaryota.
DR HOGENOM; CLU_098684_2_0_1; -.
DR InParanoid; Q8HYA9; -.
DR OMA; NILWIVN; -.
DR OrthoDB; 1464387at2759; -.
DR TreeFam; TF335950; -.
DR Proteomes; UP000008227; Chromosome 3.
DR Proteomes; UP000314985; Unplaced.
DR Bgee; ENSSSCG00000035529; Expressed in duodenum and 4 other tissues.
DR Genevisible; Q8HYA9; SS.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0030141; C:secretory granule; IEA:Ensembl.
DR GO; GO:0008083; F:growth factor activity; IEA:Ensembl.
DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR InterPro; IPR007084; BRICHOS_dom.
DR Pfam; PF04089; BRICHOS; 1.
DR SMART; SM01039; BRICHOS; 1.
DR PROSITE; PS50869; BRICHOS; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Golgi apparatus; Mitogen;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000269|PubMed:12851218"
FT CHAIN 21..185
FT /note="Gastrokine-1"
FT /id="PRO_0000021334"
FT DOMAIN 54..150
FT /note="BRICHOS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00255"
FT DISULFID 81..142
FT /evidence="ECO:0000250"
SQ SEQUENCE 185 AA; 20104 MW; 3E3A6A65BD8A5E2C CRC64;
MKFTIAFAGL LGVFLTPALA DYSISVNDDG NSGGSGQQSV SVNNEHNVAN VDNNNGWNSW
NALWDYRTGF AVTRLFEKKS CIVHKMKKEA MPSLQALDAL VKEKKLQGKG PGGPPPKSLR
YSVNPNRVDN LDKFGKSIVA MCKGIPTYMA EEIQGANLIS YSEKCISANI LWILNISFCG
GIAEN
