GKN2_HUMAN
ID GKN2_HUMAN Reviewed; 184 AA.
AC Q86XP6; Q6UWS6;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Gastrokine-2;
DE AltName: Full=Blottin;
DE AltName: Full=Down-regulated in gastric cancer;
DE AltName: Full=Trefoil factor interactions(z) 1;
DE Flags: Precursor;
GN Name=GKN2; Synonyms=BLOT, GDDR, TFIZ1; ORFNames=UNQ465/PRO813;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Stomach;
RX PubMed=12921637;
RA Du J.J., Dou K.F., Zhong M., Xiao H.S., Wang W.Z., Wang Z.H., Gao Z.Q.;
RT "Down-regulated full-length novel gene GDDR and its effect on gastric
RT cancer.";
RL Zhonghua Yi Xue Za Zhi 83:1166-1168(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Stomach;
RX PubMed=15774165;
RA Du J.J., Dou K.F., Peng S.Y., Li J.T., Liu Y.B., Wang W.Z., Guan W.X.,
RA Gao Z.Q.;
RT "Study on novel gene GDDR related to gastric cancer.";
RL Zhonghua Wai Ke Za Zhi 43:10-13(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 21-33, TISSUE SPECIFICITY,
RP AND INTERACTION WITH TFF1.
RC TISSUE=Stomach;
RX PubMed=15924415; DOI=10.1021/bi047287n;
RA Westley B.R., Griffin S.M., May F.E.B.;
RT "Interaction between TFF1, a gastric tumor suppressor trefoil protein, and
RT TFIZ1, a Brichos domain-containing protein with homology to SP-C.";
RL Biochemistry 44:7967-7975(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=16888721; DOI=10.1002/pmic.200500911;
RA Otto W.R., Patel K., McKinnell I., Evans M.D., Lee C.-Y., Frith D.,
RA Hanrahan S., Blight K., Blin N., Kayademir T., Poulsom R., Jeffery R.,
RA Hunt T., Wright N.A., McGregor F., Oien K.A.;
RT "Identification of blottin: a novel gastric trefoil factor family-2 binding
RT protein.";
RL Proteomics 6:4235-4245(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-184, AND VARIANT ASN-113.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
CC -!- SUBUNIT: Interacts with TFF2 (By similarity). Heterodimer with TFF1;
CC disulfide linked. {ECO:0000250, ECO:0000269|PubMed:15924415}.
CC -!- INTERACTION:
CC Q86XP6; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-13380976, EBI-18304435;
CC Q86XP6; Q96Q45-2: TMEM237; NbExp=3; IntAct=EBI-13380976, EBI-10982110;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in gastric mucosa.
CC {ECO:0000269|PubMed:15924415}.
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DR EMBL; AF494509; AAO85515.2; -; mRNA.
DR EMBL; AJ966788; CAI85014.1; -; mRNA.
DR EMBL; AY943908; AAY24521.1; -; mRNA.
DR EMBL; AY358664; AAQ89027.1; -; mRNA.
DR CCDS; CCDS33215.1; -.
DR RefSeq; NP_872342.2; NM_182536.2.
DR AlphaFoldDB; Q86XP6; -.
DR SMR; Q86XP6; -.
DR BioGRID; 128331; 253.
DR IntAct; Q86XP6; 2.
DR STRING; 9606.ENSP00000329292; -.
DR iPTMnet; Q86XP6; -.
DR PhosphoSitePlus; Q86XP6; -.
DR BioMuta; GKN2; -.
DR DMDM; 74750542; -.
DR MassIVE; Q86XP6; -.
DR PaxDb; Q86XP6; -.
DR PeptideAtlas; Q86XP6; -.
DR PRIDE; Q86XP6; -.
DR ProteomicsDB; 70314; -.
DR TopDownProteomics; Q86XP6; -.
DR Antibodypedia; 56589; 111 antibodies from 20 providers.
DR DNASU; 200504; -.
DR Ensembl; ENST00000328895.9; ENSP00000329292.4; ENSG00000183607.10.
DR GeneID; 200504; -.
DR KEGG; hsa:200504; -.
DR MANE-Select; ENST00000328895.9; ENSP00000329292.4; NM_182536.3; NP_872342.2.
DR UCSC; uc002sfa.3; human.
DR CTD; 200504; -.
DR DisGeNET; 200504; -.
DR GeneCards; GKN2; -.
DR HGNC; HGNC:24588; GKN2.
DR HPA; ENSG00000183607; Tissue enriched (stomach).
DR MIM; 618589; gene.
DR neXtProt; NX_Q86XP6; -.
DR OpenTargets; ENSG00000183607; -.
DR PharmGKB; PA162389760; -.
DR VEuPathDB; HostDB:ENSG00000183607; -.
DR eggNOG; ENOG502SNS6; Eukaryota.
DR GeneTree; ENSGT00930000150969; -.
DR HOGENOM; CLU_098684_2_0_1; -.
DR InParanoid; Q86XP6; -.
DR OMA; IFGTQSH; -.
DR OrthoDB; 1298343at2759; -.
DR PhylomeDB; Q86XP6; -.
DR TreeFam; TF335950; -.
DR PathwayCommons; Q86XP6; -.
DR SignaLink; Q86XP6; -.
DR BioGRID-ORCS; 200504; 17 hits in 1059 CRISPR screens.
DR ChiTaRS; GKN2; human.
DR GenomeRNAi; 200504; -.
DR Pharos; Q86XP6; Tbio.
DR PRO; PR:Q86XP6; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q86XP6; protein.
DR Bgee; ENSG00000183607; Expressed in mucosa of stomach and 106 other tissues.
DR ExpressionAtlas; Q86XP6; baseline and differential.
DR Genevisible; Q86XP6; HS.
DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0009617; P:response to bacterium; IEA:Ensembl.
DR InterPro; IPR007084; BRICHOS_dom.
DR Pfam; PF04089; BRICHOS; 1.
DR SMART; SM01039; BRICHOS; 1.
DR PROSITE; PS50869; BRICHOS; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..184
FT /note="Gastrokine-2"
FT /id="PRO_0000252104"
FT DOMAIN 54..151
FT /note="BRICHOS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00255"
FT DISULFID 81..143
FT /evidence="ECO:0000250"
FT VARIANT 113
FT /note="S -> N (in dbSNP:rs1128272)"
FT /evidence="ECO:0000269|PubMed:12975309"
FT /id="VAR_051012"
FT CONFLICT 9
FT /note="V -> M (in Ref. 5; AAQ89027)"
FT /evidence="ECO:0000305"
FT CONFLICT 51
FT /note="I -> V (in Ref. 5; AAQ89027)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 184 AA; 20487 MW; 84B08AF978173AA5 CRC64;
MKILVAFLVV LTIFGIQSHG YEVFNIISPS NNGGNVQETV TIDNEKNTAI INIHAGSCSS
TTIFDYKHGY IASRVLSRRA CFILKMDHQN IPPLNNLQWY IYEKQALDNM FSSKYTWVKY
NPLESLIKDV DWFLLGSPIE KLCKHIPLYK GEVVENTHNV GAGGCAKAGL LGILGISICA
DIHV
