ID   GKN2_RAT                Reviewed;         184 AA.
AC   Q29TV8;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Gastrokine-2;
DE   AltName: Full=Blottin;
DE   Flags: Precursor;
GN   Name=Gkn2; Synonyms=Blot;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=16888721; DOI=10.1002/pmic.200500911;
RA   Otto W.R., Patel K., McKinnell I., Evans M.D., Lee C.-Y., Frith D.,
RA   Hanrahan S., Blight K., Blin N., Kayademir T., Poulsom R., Jeffery R.,
RA   Hunt T., Wright N.A., McGregor F., Oien K.A.;
RT   "Identification of blottin: a novel gastric trefoil factor family-2 binding
RT   protein.";
RL   Proteomics 6:4235-4245(2006).
CC   -!- SUBUNIT: Heterodimer with TFF1; disulfide linked. Interacts with TFF2
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY943907; AAY24520.1; -; mRNA.
DR   RefSeq; NP_001034775.1; NM_001039686.1.
DR   AlphaFoldDB; Q29TV8; -.
DR   SMR; Q29TV8; -.
DR   STRING; 10116.ENSRNOP00000063736; -.
DR   iPTMnet; Q29TV8; -.
DR   PhosphoSitePlus; Q29TV8; -.
DR   PaxDb; Q29TV8; -.
DR   PRIDE; Q29TV8; -.
DR   Ensembl; ENSRNOT00000067651; ENSRNOP00000063736; ENSRNOG00000009256.
DR   GeneID; 297419; -.
DR   KEGG; rno:297419; -.
DR   UCSC; RGD:1311934; rat.
DR   CTD; 200504; -.
DR   RGD; 1311934; Gkn2.
DR   eggNOG; ENOG502SNS6; Eukaryota.
DR   GeneTree; ENSGT00930000150969; -.
DR   HOGENOM; CLU_098684_2_0_1; -.
DR   InParanoid; Q29TV8; -.
DR   OMA; IFGTQSH; -.
DR   OrthoDB; 1298343at2759; -.
DR   PhylomeDB; Q29TV8; -.
DR   TreeFam; TF335950; -.
DR   PRO; PR:Q29TV8; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000009256; Expressed in stomach and 16 other tissues.
DR   Genevisible; Q29TV8; RN.
DR   GO; GO:0045178; C:basal part of cell; ISO:RGD.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR   GO; GO:0009617; P:response to bacterium; ISO:RGD.
DR   InterPro; IPR007084; BRICHOS_dom.
DR   Pfam; PF04089; BRICHOS; 1.
DR   SMART; SM01039; BRICHOS; 1.
DR   PROSITE; PS50869; BRICHOS; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..184
FT                   /note="Gastrokine-2"
FT                   /id="PRO_0000252131"
FT   DOMAIN          54..151
FT                   /note="BRICHOS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00255"
FT   DISULFID        81..143
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   184 AA;  20369 MW;  4A5DBD583BDA7072 CRC64;
     MKSLVAFLVV LSILRIQSQA KEVFNIFVPG NNGGNVQETV TIDNQENTAT INIHSGSCSS
     TTIFDYKHGY IASRVLSRRA CYIIKMDHKA IPALDKLQRF LYEKQTMNAM ASTEYTWVKY
     NPLKSLITKV DWFLFGSPIE QLCKHIPLYE GEVATKPREV GTGGCAKVGI LGILGISICG
     GIHL