GKN3_HUMAN
ID GKN3_HUMAN Reviewed; 181 AA.
AC P0CG01;
DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 1.
DT 25-MAY-2022, entry version 38.
DE RecName: Full=Gastrokine-3;
DE Flags: Precursor;
GN Name=GKN3P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP IDENTIFICATION, AND POLYMORPHISM.
RX PubMed=20138039; DOI=10.1053/j.gastro.2010.01.050;
RA Menheniott T.R., Peterson A.J., O'Connor L., Lee K.S., Kalantzis A.,
RA Kondova I., Bontrop R.E., Bell K.M., Giraud A.S.;
RT "A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of
RT adaptive gene loss in humans.";
RL Gastroenterology 138:1823-1835(2010).
CC -!- FUNCTION: May inhibit gastric epithelial cell proliferation.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- POLYMORPHISM: The most frequent variant has a stop codon instead of
CC Trp-59, triggering nonsense-mediated decay (PubMed:20138039). The
CC variant Trp-59 is rare, except in some populations from Africa
CC (PubMed:20138039). {ECO:0000269|PubMed:20138039}.
CC -!- SIMILARITY: Belongs to the gastrokine family. {ECO:0000305}.
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DR EMBL; AC097495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P0CG01; -.
DR PhosphoSitePlus; P0CG01; -.
DR BioMuta; HGNC:37701; -.
DR DMDM; 298351691; -.
DR PRIDE; P0CG01; -.
DR GeneCards; GKN3P; -.
DR HGNC; HGNC:37701; GKN3P.
DR neXtProt; NX_P0CG01; -.
DR InParanoid; P0CG01; -.
DR PhylomeDB; P0CG01; -.
DR Pharos; P0CG01; Tdark.
DR PRO; PR:P0CG01; -.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0CG01; protein.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR InterPro; IPR007084; BRICHOS_dom.
DR Pfam; PF04089; BRICHOS; 1.
DR SMART; SM01039; BRICHOS; 1.
DR PROSITE; PS50869; BRICHOS; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..181
FT /note="Gastrokine-3"
FT /id="PRO_0000394473"
FT DOMAIN 53..145
FT /note="BRICHOS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00255"
FT DISULFID 80..137
FT /evidence="ECO:0000250"
SQ SEQUENCE 181 AA; 20221 MW; A0473854F788120E CRC64;
MKHLVASSIL GVFVLTPSLA MMNIRFNHPL YGSFGTQIIH IGAFQGMVSI RDNNIFSEWD
GILDYKNALL VAKVFNKMAC VLARMDKAVF PSLDDISKAL DKQAFKYYPS TRGLTYTVLP
SWVKNLAQYG KPIKNMCRDD PTYFAQQQKE GTALAIDSNS CFEIQLLSFM GLFICGETPG
L
