ID   GKN3_PIG                Reviewed;         181 AA.
AC   D2XPP7;
DT   15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 1.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Gastrokine-3;
DE   Flags: Precursor;
GN   Name=GKN3;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Stomach;
RX   PubMed=20138039; DOI=10.1053/j.gastro.2010.01.050;
RA   Menheniott T.R., Peterson A.J., O'Connor L., Lee K.S., Kalantzis A.,
RA   Kondova I., Bontrop R.E., Bell K.M., Giraud A.S.;
RT   "A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence of
RT   adaptive gene loss in humans.";
RL   Gastroenterology 138:1823-1835(2010).
CC   -!- FUNCTION: May inhibit gastric epithelial cell proliferation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the gastrokine family. {ECO:0000305}.
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DR   EMBL; GU228900; ADB28878.1; -; mRNA.
DR   RefSeq; NP_001165509.1; NM_001172038.1.
DR   RefSeq; XP_003481241.1; XM_003481193.2.
DR   AlphaFoldDB; D2XPP7; -.
DR   PaxDb; D2XPP7; -.
DR   PeptideAtlas; D2XPP7; -.
DR   PRIDE; D2XPP7; -.
DR   Ensembl; ENSSSCT00025052594; ENSSSCP00025022429; ENSSSCG00025038598.
DR   Ensembl; ENSSSCT00035083002; ENSSSCP00035034459; ENSSSCG00035061768.
DR   Ensembl; ENSSSCT00040022413; ENSSSCP00040009385; ENSSSCG00040016628.
DR   Ensembl; ENSSSCT00045032505; ENSSSCP00045022507; ENSSSCG00045019046.
DR   Ensembl; ENSSSCT00055029068; ENSSSCP00055023145; ENSSSCG00055014673.
DR   Ensembl; ENSSSCT00065021152; ENSSSCP00065008548; ENSSSCG00065015940.
DR   Ensembl; ENSSSCT00070060150; ENSSSCP00070051248; ENSSSCG00070029932.
DR   GeneID; 100329220; -.
DR   KEGG; ssc:100329220; -.
DR   CTD; 68888; -.
DR   eggNOG; ENOG502S4AB; Eukaryota.
DR   HOGENOM; CLU_098684_1_0_1; -.
DR   InParanoid; D2XPP7; -.
DR   OrthoDB; 1205514at2759; -.
DR   TreeFam; TF335950; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Chromosome 3.
DR   Genevisible; D2XPP7; SS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR   InterPro; IPR007084; BRICHOS_dom.
DR   Pfam; PF04089; BRICHOS; 1.
DR   SMART; SM01039; BRICHOS; 1.
DR   PROSITE; PS50869; BRICHOS; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..181
FT                   /note="Gastrokine-3"
FT                   /id="PRO_0000394475"
FT   DOMAIN          53..145
FT                   /note="BRICHOS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00255"
FT   DISULFID        80..137
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   181 AA;  19684 MW;  85D11F6D54733485 CRC64;
     MKYLMASSVF VLFILAPSLA LMNPGDGHPQ EGSVGSQSIR VNALGSMISI RDNNVLSEWD
     GILDYENGLL AAKLFSKMAC VLTKMDKAVF PTLDDISKAL DHQALKHYPS TRGLTYTVLP
     SRVKNLAQYG VPIKDMCRDV PTYFAQQQKE GTALAIDPDS CSEIQLLSFL GLSICGEIPG
     L