ID   GL15L_PIG               Reviewed;          81 AA.
AC   I3LGZ3;
DT   20-DEC-2017, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2012, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Protein GPR15L {ECO:0000303|PubMed:28900043};
DE   Flags: Precursor;
GN   Name=GPRL15 {ECO:0000303|PubMed:28900043};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc;
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 25-81, IDENTIFICATION BY MASS SPECTROMETRY, DISULFIDE
RP   BOND, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=28900043; DOI=10.1126/scisignal.aal0180;
RA   Suply T., Hannedouche S., Carte N., Li J., Grosshans B., Schaefer M.,
RA   Raad L., Beck V., Vidal S., Hiou-Feige A., Beluch N., Barbieri S.,
RA   Wirsching J., Lageyre N., Hillger F., Debon C., Dawson J., Smith P.,
RA   Lannoy V., Detheux M., Bitsch F., Falchetto R., Bouwmeester T., Porter J.,
RA   Baumgarten B., Mansfield K., Carballido J.M., Seuwen K., Bassilana F.;
RT   "A natural ligand for the orphan receptor GPR15 modulates lymphocyte
RT   recruitment to epithelia.";
RL   Sci. Signal. 10:0-0(2017).
CC   -!- FUNCTION: Chemotactic factor that mediates lymphocytes recruitment to
CC       epithelia through binding and activation of the G-protein coupled
CC       receptor GPR15 (PubMed:28900043). May be a tumor suppressor; together
CC       with SUSD2 has a growth inhibitory effect on colon cancer cells which
CC       includes G1 cell cycle arrest (By similarity).
CC       {ECO:0000250|UniProtKB:Q6UWK7, ECO:0000269|PubMed:28900043}.
CC   -!- FUNCTION: Has antimicrobial activity against Gram-positive bacteria,
CC       including Staphylococcus aureus and Actinomyces spec., and Mycoplasma
CC       hominis and lentivirus. {ECO:0000250|UniProtKB:Q6UWK7}.
CC   -!- SUBUNIT: Interacts with SUSD2; the interaction is direct.
CC       {ECO:0000250|UniProtKB:Q6UWK7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28900043}.
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DR   EMBL; CU633218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001230830.1; NM_001243901.1.
DR   RefSeq; XP_013838838.1; XM_013983384.1.
DR   AlphaFoldDB; I3LGZ3; -.
DR   STRING; 9823.ENSSSCP00000023337; -.
DR   PaxDb; I3LGZ3; -.
DR   PRIDE; I3LGZ3; -.
DR   Ensembl; ENSSSCT00000027651; ENSSSCP00000023337; ENSSSCG00000024634.
DR   Ensembl; ENSSSCT00005043284; ENSSSCP00005026535; ENSSSCG00005027303.
DR   Ensembl; ENSSSCT00015049122; ENSSSCP00015019565; ENSSSCG00015036917.
DR   Ensembl; ENSSSCT00030024779; ENSSSCP00030011062; ENSSSCG00030017955.
DR   Ensembl; ENSSSCT00035051564; ENSSSCP00035020672; ENSSSCG00035038854.
DR   Ensembl; ENSSSCT00040072356; ENSSSCP00040030904; ENSSSCG00040053543.
DR   Ensembl; ENSSSCT00045016322; ENSSSCP00045011279; ENSSSCG00045009625.
DR   Ensembl; ENSSSCT00050014574; ENSSSCP00050006000; ENSSSCG00050010836.
DR   Ensembl; ENSSSCT00055040279; ENSSSCP00055032047; ENSSSCG00055020551.
DR   Ensembl; ENSSSCT00060082425; ENSSSCP00060035693; ENSSSCG00060060432.
DR   Ensembl; ENSSSCT00065025184; ENSSSCP00065010300; ENSSSCG00065018940.
DR   Ensembl; ENSSSCT00070000727; ENSSSCP00070000637; ENSSSCG00070000399.
DR   GeneID; 100511838; -.
DR   KEGG; ssc:100511838; -.
DR   CTD; 100511838; -.
DR   eggNOG; ENOG502TD47; Eukaryota.
DR   GeneTree; ENSGT00390000015172; -.
DR   HOGENOM; CLU_195436_0_0_1; -.
DR   InParanoid; I3LGZ3; -.
DR   OMA; LTNPKGH; -.
DR   OrthoDB; 1583928at2759; -.
DR   TreeFam; TF336385; -.
DR   Proteomes; UP000008227; Chromosome 14.
DR   Proteomes; UP000314985; Chromosome 14.
DR   Bgee; ENSSSCG00000024634; Expressed in penis and 23 other tissues.
DR   Genevisible; I3LGZ3; SS.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0008009; F:chemokine activity; ISS:UniProtKB.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; ISS:UniProtKB.
DR   GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
DR   GO; GO:0050832; P:defense response to fungus; IEA:Ensembl.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IEA:Ensembl.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0048247; P:lymphocyte chemotaxis; ISS:UniProtKB.
DR   GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; IEA:Ensembl.
DR   GO; GO:0051782; P:negative regulation of cell division; IEA:Ensembl.
DR   GO; GO:2000404; P:regulation of T cell migration; ISS:UniProtKB.
DR   InterPro; IPR031713; GPR15L.
DR   Pfam; PF15854; GPR15L; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Chemotaxis; Cytokine; Direct protein sequencing;
KW   Disulfide bond; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000269|PubMed:28900043"
FT   CHAIN           25..81
FT                   /note="Protein GPR15L"
FT                   /id="PRO_5003675598"
FT   DISULFID        40..63
FT                   /evidence="ECO:0000269|PubMed:28900043"
FT   DISULFID        41..60
FT                   /evidence="ECO:0000269|PubMed:28900043"
SQ   SEQUENCE   81 AA;  9214 MW;  58E8EC0EC5D42EE6 CRC64;
     MRFLALTSLL CILLLCLSFF SAEGRRHPRN PAKPGKIRIC CPRLPGPDLM PQKGHHMRIC
     RPCKFKQKPQ LWVVPGALPQ V