GL1D1_MOUSE
ID GL1D1_MOUSE Reviewed; 346 AA.
AC A4FUP9; Q8BWP4;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Glycosyltransferase 1 domain-containing protein 1;
DE EC=2.4.-.-;
DE Flags: Precursor;
GN Name=Glt1d1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-220 (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A4FUP9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A4FUP9-2; Sequence=VSP_029734, VSP_029735;
CC -!- SIMILARITY: Belongs to the glycosyltransferase group 1 family.
CC Glycosyltransferase 4 subfamily. {ECO:0000305}.
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DR EMBL; AK050379; BAC34221.1; -; mRNA.
DR EMBL; AC144908; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC115464; AAI15465.1; -; mRNA.
DR CCDS; CCDS51651.1; -. [A4FUP9-1]
DR RefSeq; NP_795979.2; NM_177005.4. [A4FUP9-1]
DR AlphaFoldDB; A4FUP9; -.
DR SMR; A4FUP9; -.
DR BioGRID; 235537; 1.
DR STRING; 10090.ENSMUSP00000113864; -.
DR CAZy; GT4; Glycosyltransferase Family 4.
DR MaxQB; A4FUP9; -.
DR PaxDb; A4FUP9; -.
DR PRIDE; A4FUP9; -.
DR ProteomicsDB; 268827; -. [A4FUP9-1]
DR ProteomicsDB; 268828; -. [A4FUP9-2]
DR Antibodypedia; 31929; 60 antibodies from 12 providers.
DR DNASU; 319804; -.
DR Ensembl; ENSMUST00000118139; ENSMUSP00000113864; ENSMUSG00000049971. [A4FUP9-1]
DR GeneID; 319804; -.
DR KEGG; mmu:319804; -.
DR UCSC; uc008zsd.1; mouse. [A4FUP9-1]
DR CTD; 144423; -.
DR MGI; MGI:2442755; Glt1d1.
DR VEuPathDB; HostDB:ENSMUSG00000049971; -.
DR eggNOG; ENOG502QQZE; Eukaryota.
DR GeneTree; ENSGT00390000016790; -.
DR HOGENOM; CLU_009583_7_1_1; -.
DR InParanoid; A4FUP9; -.
DR OMA; FEGGMAN; -.
DR OrthoDB; 987386at2759; -.
DR PhylomeDB; A4FUP9; -.
DR TreeFam; TF331382; -.
DR BioGRID-ORCS; 319804; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Glt1d1; mouse.
DR PRO; PR:A4FUP9; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; A4FUP9; protein.
DR Bgee; ENSMUSG00000049971; Expressed in spermatid and 52 other tissues.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR InterPro; IPR001296; Glyco_trans_1.
DR Pfam; PF00534; Glycos_transf_1; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycosyltransferase; Reference proteome; Secreted;
KW Signal; Transferase.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..346
FT /note="Glycosyltransferase 1 domain-containing protein 1"
FT /id="PRO_0000312204"
FT VAR_SEQ 138..159
FT /note="GIATIPNANFNWNTFLQQSEID -> VAEAGRTRMCRPHRPLLASSCH (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029734"
FT VAR_SEQ 160..346
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029735"
FT CONFLICT 75
FT /note="S -> G (in Ref. 3; AAI15465)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 346 AA; 38841 MW; 53F70590B86A320C CRC64;
MRLLFLAVLR PHTGNAVTAG RLRDHLEAAG HMCVLRDAFD FESPSEIANL IMDENLEAAL
ALHLYRGGRL LQGHSIPFGV IFGGTDLNED ANHKEKKEVM GKVLEEARFA VAFTEAMKDT
AQVQWPHATG KIFVQSQGIA TIPNANFNWN TFLQQSEIDQ SADNLYIFLI ICGLRPVKDP
LYLVDAFSEW HQETPNVYMV IVGPEVDPVF TREVKERVRR AAGVRLIREM CQEDLHAVVK
SCFALVNSSV SEGMSAAILE AMDLEVPVLA RNIPGNSAVV EHGVTGLLFS NPQEFIQLAK
RLVSDPALEK EIVTNGREYV RTHHSWQVER DTYQRLIRKL ETNLED
