ID   GL6D1_BOVIN             Reviewed;         308 AA.
AC   Q2YDM8;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Glycosyltransferase 6 domain-containing protein 1;
DE            EC=2.4.1.-;
GN   Name=GLT6D1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000250|UniProtKB:P14769};
CC       Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250|UniProtKB:P14769};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 6 family. {ECO:0000305}.
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DR   EMBL; BC110149; AAI10150.1; -; mRNA.
DR   RefSeq; NP_001069396.1; NM_001075928.2.
DR   AlphaFoldDB; Q2YDM8; -.
DR   SMR; Q2YDM8; -.
DR   STRING; 9913.ENSBTAP00000040449; -.
DR   CAZy; GT6; Glycosyltransferase Family 6.
DR   PaxDb; Q2YDM8; -.
DR   GeneID; 529958; -.
DR   KEGG; bta:529958; -.
DR   CTD; 360203; -.
DR   eggNOG; ENOG502RU0J; Eukaryota.
DR   InParanoid; Q2YDM8; -.
DR   OrthoDB; 1204439at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005076; Glyco_trans_6.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR10462; PTHR10462; 1.
DR   Pfam; PF03414; Glyco_transf_6; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Glycosyltransferase; Membrane; Reference proteome;
KW   Signal-anchor; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..308
FT                   /note="Glycosyltransferase 6 domain-containing protein 1"
FT                   /id="PRO_0000311970"
FT   TOPO_DOM        1..6
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..23
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        24..308
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        263
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250|UniProtKB:P14769"
FT   BINDING         83..88
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:P14769"
FT   BINDING         173..175
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:P14769"
FT   BINDING         195..198
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:P14769"
FT   CARBOHYD        75
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   308 AA;  36517 MW;  D84A150E04A9314B CRC64;
     MNCKRKMLLL IQGLSLLLLF DHYSRKNQEE ELELSDWFKP RGRPDVITTT SWLAPVVWEG
     TFSRKMLEKH YRRQNFTTGL AVFATGRLAD PYLELFLNSA NKYFLTGYRV IFYIMMDTFI
     KLPQIKWEPL RQFKVFIVTE SRWWDNDVVR MKSLAKHIIW DIQGEVDFLF SMTVTQIFQN
     NVGVEVLGEL VAQLHGWWYF KDRASFPYER RPKSAAYIPF GQGDFYYDGA FVGGTPQEVL
     NLAEEYLNGV IHDLGLRLNS SYEKHLNKYF FLRKPTKLLS PEYNWDADFY PPPQVQYVKV
     AQQSKRRH