ID   GL6D1_MACFA             Reviewed;         308 AA.
AC   Q4R5T7; Q9BH00;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 2.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Glycosyltransferase 6 domain-containing protein 1;
DE            EC=2.4.1.-;
GN   Name=GLT6D1; ORFNames=QflA-10350, QtsA-20904;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Frontal cortex;
RX   PubMed=11806829; DOI=10.1186/gb-2001-3-1-research0006;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Prediction of unidentified human genes on the basis of sequence similarity
RT   to novel cDNAs from cynomolgus monkey brain.";
RL   Genome Biol. 3:RESEARCH0006.1-RESEARCH0006.5(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000250|UniProtKB:P14769};
CC       Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000250|UniProtKB:P14769};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 6 family. {ECO:0000305}.
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DR   EMBL; AB055256; BAB21880.1; -; mRNA.
DR   EMBL; AB169456; BAE01538.1; -; mRNA.
DR   RefSeq; NP_001270822.1; NM_001283893.1.
DR   AlphaFoldDB; Q4R5T7; -.
DR   SMR; Q4R5T7; -.
DR   STRING; 9541.XP_005580515.1; -.
DR   CAZy; GT6; Glycosyltransferase Family 6.
DR   GeneID; 101865068; -.
DR   CTD; 360203; -.
DR   eggNOG; ENOG502RU0J; Eukaryota.
DR   OrthoDB; 1204439at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016758; F:hexosyltransferase activity; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR005076; Glyco_trans_6.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   PANTHER; PTHR10462; PTHR10462; 1.
DR   Pfam; PF03414; Glyco_transf_6; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Glycosyltransferase; Membrane; Reference proteome;
KW   Signal-anchor; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..308
FT                   /note="Glycosyltransferase 6 domain-containing protein 1"
FT                   /id="PRO_0000311972"
FT   TOPO_DOM        1..6
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        7..23
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        24..308
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   ACT_SITE        263
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250|UniProtKB:P14769"
FT   BINDING         82..87
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:P14769"
FT   BINDING         173..175
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:P14769"
FT   BINDING         195..198
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:P14769"
FT   CARBOHYD        74
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        4
FT                   /note="K -> R (in Ref. 1; BAE01538)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        81
FT                   /note="V -> F (in Ref. 1; BAB21880)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        218
FT                   /note="I -> T (in Ref. 1; BAB21880)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   308 AA;  36420 MW;  94384DC1EF1BBE5E CRC64;
     MNSKRMLLLV LFAFSLMLVE RYFRNHQVEE LRLSDWFHPR KRPDVITKTD WLAPIVWEGT
     FDRQVLEKHY RRRNITVGLA VFATGRFAEE YLRLFLHSAN KHFMTGYRVI FYIMVDAFLQ
     LPDIQPSPLR TFKAFEVDAE RWWLEGSLVY MKSLGEHITS HIQDEVDFLF SMAVNQVFQN
     EFGVETLGPL VAQLHAWWYF RNTKNFPYER RPTSAASIPF GQGDFYYGSL MVGGTPRNIL
     DFIEEYLNGV IHDIKNGLNS TYEKHLNKYF YLNKPTKLLS PEYSWDLAFS PPPQIQYVKV
     AHDSHRKL