GL8D2_MOUSE
ID GL8D2_MOUSE Reviewed; 349 AA.
AC Q640P4; Q9D163;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Glycosyltransferase 8 domain-containing protein 2;
DE EC=2.4.1.-;
GN Name=Glt8d2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 8 family. {ECO:0000305}.
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DR EMBL; AK003894; BAB23061.1; -; mRNA.
DR EMBL; BC082561; AAH82561.1; -; mRNA.
DR CCDS; CCDS24071.1; -.
DR RefSeq; NP_083378.2; NM_029102.3.
DR AlphaFoldDB; Q640P4; -.
DR SMR; Q640P4; -.
DR BioGRID; 217016; 2.
DR STRING; 10090.ENSMUSP00000020485; -.
DR CAZy; GT8; Glycosyltransferase Family 8.
DR GlyGen; Q640P4; 1 site.
DR iPTMnet; Q640P4; -.
DR PhosphoSitePlus; Q640P4; -.
DR MaxQB; Q640P4; -.
DR PaxDb; Q640P4; -.
DR PRIDE; Q640P4; -.
DR ProteomicsDB; 266807; -.
DR DNASU; 74782; -.
DR Ensembl; ENSMUST00000020485; ENSMUSP00000020485; ENSMUSG00000020251.
DR GeneID; 74782; -.
DR KEGG; mmu:74782; -.
DR CTD; 83468; -.
DR MGI; MGI:1922032; Glt8d2.
DR eggNOG; ENOG502QTN8; Eukaryota.
DR GeneTree; ENSGT00940000158078; -.
DR InParanoid; Q640P4; -.
DR OrthoDB; 1520602at2759; -.
DR PhylomeDB; Q640P4; -.
DR BioGRID-ORCS; 74782; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Glt8d2; mouse.
DR PRO; PR:Q640P4; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q640P4; protein.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.90.550.10; -; 1.
DR InterPro; IPR002495; Glyco_trans_8.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR Pfam; PF01501; Glyco_transf_8; 1.
DR SUPFAM; SSF53448; SSF53448; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Glycosyltransferase; Membrane; Reference proteome;
KW Signal-anchor; Transferase; Transmembrane; Transmembrane helix.
FT CHAIN 1..349
FT /note="Glycosyltransferase 8 domain-containing protein 2"
FT /id="PRO_0000271384"
FT TOPO_DOM 1..6
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 7..24
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 25..349
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT CARBOHYD 234
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 243
FT /note="I -> V (in Ref. 2; BAB23061)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 349 AA; 39933 MW; 591A7C87496648F7 CRC64;
MAFLRKVNQV LLLLLVLTLC GILYKKVHKG AVLKDKADVD SESPEDMEEE IPVVICAAAG
RMGAAMAAIN SIYSNTDANL VFYVVGLRST LPRIRKWIEH SKLREINFKI VEFNPTVLKG
KIRPDSSRPE LLQPLNFVRF YLPLLVHQHE KVIYLDDDVI VQGDIQELYD TTLALGHAAA
FSDDCDLPSA QDIHRLVGLQ NTYMGYLDYR KKTIKDLGIS PSTCSFNPGV IVANMTEWKH
QRITKQLEKW MQKNVEENLY SSSLGGGVAT SPMLIVFHGK YSTINPLWHI RHLGWNPDAR
YSEHFLQEAK LLHWNGRHKP WDFPSVHNDL WESWFVPDPA GIFKLHHNR
