GLAS_DROME
ID GLAS_DROME Reviewed; 604 AA.
AC P13360; Q95T58; Q9VE83; Q9VE84;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 02-FEB-2004, sequence version 2.
DT 03-AUG-2022, entry version 188.
DE RecName: Full=Protein glass;
GN Name=gl; ORFNames=CG7672;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A).
RX PubMed=2770860; DOI=10.1038/340531a0;
RA Moses K., Ellis M.C., Rubin G.M.;
RT "The glass gene encodes a zinc-finger protein required by Drosophila
RT photoreceptor cells.";
RL Nature 340:531-536(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP FUNCTION, AND DNA-BINDING ACTIVITY.
RX PubMed=7604032; DOI=10.1073/pnas.92.14.6557;
RA O'Neill E.M., Ellis M.C., Rubin G.M., Tjian R.;
RT "Functional domain analysis of glass, a zinc-finger-containing
RT transcription factor in Drosophila.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:6557-6561(1995).
CC -!- FUNCTION: Transcription factor required for gene expression specific to
CC photoreceptor cells. {ECO:0000269|PubMed:7604032}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=P13360-1; Sequence=Displayed;
CC Name=B;
CC IsoId=P13360-2; Sequence=VSP_009352;
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DR EMBL; X15400; CAA33450.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF55543.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF55544.2; -; Genomic_DNA.
DR EMBL; AY060322; AAL25361.1; -; mRNA.
DR PIR; S05447; S05447.
DR RefSeq; NP_476854.1; NM_057506.3. [P13360-1]
DR RefSeq; NP_732330.1; NM_169807.4. [P13360-2]
DR AlphaFoldDB; P13360; -.
DR SMR; P13360; -.
DR BioGRID; 67226; 23.
DR IntAct; P13360; 4.
DR STRING; 7227.FBpp0083005; -.
DR PaxDb; P13360; -.
DR EnsemblMetazoa; FBtr0083584; FBpp0083005; FBgn0004618. [P13360-1]
DR EnsemblMetazoa; FBtr0083585; FBpp0083006; FBgn0004618. [P13360-2]
DR GeneID; 42210; -.
DR KEGG; dme:Dmel_CG7672; -.
DR CTD; 42210; -.
DR FlyBase; FBgn0004618; gl.
DR VEuPathDB; VectorBase:FBgn0004618; -.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; P13360; -.
DR OMA; DMKPNLC; -.
DR PhylomeDB; P13360; -.
DR SignaLink; P13360; -.
DR BioGRID-ORCS; 42210; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 42210; -.
DR PRO; PR:P13360; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0004618; Expressed in eye disc (Drosophila) and 14 other tissues.
DR ExpressionAtlas; P13360; baseline and differential.
DR Genevisible; P13360; DM.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IMP:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:FlyBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0060086; P:circadian temperature homeostasis; IMP:FlyBase.
DR GO; GO:0001745; P:compound eye morphogenesis; IMP:FlyBase.
DR GO; GO:0001751; P:compound eye photoreceptor cell differentiation; IMP:FlyBase.
DR GO; GO:0001752; P:compound eye photoreceptor fate commitment; IMP:FlyBase.
DR GO; GO:0009649; P:entrainment of circadian clock; IMP:FlyBase.
DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IMP:FlyBase.
DR GO; GO:0046530; P:photoreceptor cell differentiation; IMP:FlyBase.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0010114; P:response to red light; IMP:FlyBase.
DR GO; GO:0035271; P:ring gland development; IMP:FlyBase.
DR GO; GO:0007605; P:sensory perception of sound; IMP:FlyBase.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Sensory transduction; Transcription;
KW Transcription regulation; Vision; Zinc; Zinc-finger.
FT CHAIN 1..604
FT /note="Protein glass"
FT /id="PRO_0000046939"
FT ZN_FING 437..459
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 465..487
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 493..515
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 521..543
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 549..571
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 111..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 566..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 369..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 558..604
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000303|PubMed:12537569"
FT /id="VSP_009352"
FT CONFLICT 60
FT /note="Q -> E (in Ref. 1; CAA33450)"
FT /evidence="ECO:0000305"
FT CONFLICT 361
FT /note="P -> S (in Ref. 1; cDNA)"
FT /evidence="ECO:0000305"
FT CONFLICT 362
FT /note="L -> M (in Ref. 1; CAA33450)"
FT /evidence="ECO:0000305"
FT CONFLICT 377
FT /note="S -> T (in Ref. 1; cDNA)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 604 AA; 62510 MW; D73C037D56D707AA CRC64;
MGLLYKGSKL LNTILDSLED QEGGAMYISC DVSNGGPVEP ETGYVPNNPL FGLALDSPQQ
ECAASCVGCL SCQGSTALPI SSLTSSDFDC GGCFDPTIGV GVGIGGGHIQ ISTTPPASSG
NGSSNNGAGG GSSGNHGYWS TDEMASTFPG LPPLDIDPLP SLFPFSPCGA SYNFAAGNPH
QAASLSYTVH PHQMLISPNS HNHGQMHSQH QQHQHQQSQV QASHVGNSLL QSSGGNNIGS
NGSAGGVANA ASCYYETSAG TAAPPPPPAA AMYPSMSVNV SMNMTMHHGY GAGDAGGVPM
QCSQMNWTPP SNSTSAAAAA AAVNVLYPPL LSPGHYPASA TYSFTADFRA PAPTGLGALP
PLTVGEKESP SPPANSSLAG YYPTGVGNQG YTPPHKSPTS YQAAALGLSL SAFEDEEDSN
EDLDGDEGSS GGEMKPNLCR LCGKTYARPS TLKTHLRTHS GERPYRCPDC NKSFSQAANL
TAHVRTHTGQ KPFRCPICDR RFSQSSSVTT HMRTHSGERP YRCSSCKKSF SDSSTLTKHL
RIHSGEKPYQ CKLCLLRFSQ SGNLNRHMRV HGNNNSSNGS NGATGVGGES STGSGVGGGN
SLLT
