ID   GLAS_DROVI              Reviewed;         598 AA.
AC   Q24732; B4M3Z9;
DT   02-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Protein glass;
GN   Name=gl; ORFNames=GJ10836;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7604032; DOI=10.1073/pnas.92.14.6557;
RA   O'Neill E.M., Ellis M.C., Rubin G.M., Tjian R.;
RT   "Functional domain analysis of glass, a zinc-finger-containing
RT   transcription factor in Drosophila.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:6557-6561(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Transcription factor required for gene expression specific to
CC       photoreceptor cells. {ECO:0000250|UniProtKB:P13360}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U39746; AAA85272.1; -; Genomic_DNA.
DR   EMBL; CH940652; EDW59360.1; -; Genomic_DNA.
DR   RefSeq; XP_002056248.2; XM_002056212.2.
DR   AlphaFoldDB; Q24732; -.
DR   SMR; Q24732; -.
DR   STRING; 7244.FBpp0225253; -.
DR   PRIDE; Q24732; -.
DR   EnsemblMetazoa; FBtr0226761; FBpp0225253; FBgn0015211.
DR   GeneID; 6632850; -.
DR   KEGG; dvi:6632850; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   HOGENOM; CLU_018155_1_1_1; -.
DR   InParanoid; Q24732; -.
DR   OMA; DMKPNLC; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q24732; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Sensory transduction; Transcription; Transcription regulation; Vision;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..598
FT                   /note="Protein glass"
FT                   /id="PRO_0000046940"
FT   ZN_FING         427..449
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         455..477
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         483..505
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         511..533
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         539..561
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          192..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          402..422
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          559..598
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        192..243
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        402..416
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        559..591
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   598 AA;  61774 MW;  B51EB90E85E84FD6 CRC64;
     MGLLYKGSKL LNIILDSLED QEGGAMYISC DVSNGGPVEP ETGYVPNNPL FGLALDSPQQ
     ECAASCVGCL SCQGNTALPI SSLTSSDFDC GGCFDPTIGV LGSQINTTPP ASNLSASGSG
     VGNHNNGAAL AGNGNSYWST DEMASTFPGL PPLDIDPLPS LFPFSPCGAS YNFASNPHQA
     SLSYTVHPHQ MLISPNGSQQ QQSQSSTHPH QLQSQHMQQA LTQASHGGNA LHNHNSSGGN
     GPGGGGGSGS GSACYYEAAT NAPAPPMYPS MSVNVSMNMT MHHGYGADGG PVPMQCSQMN
     WTPPSNSSAA VNVLYPPLLS PTHYPASATY SFTADFRAPP PTALGALPSL ADKESPSPPA
     SSTAAALGYY ATGGVGQGYT PPHKSPSYQA AALSLGLAAF EDEEESIEDG DADADGEGSA
     GGDMKPNLCR LCGKTYARPS TLKTHLRTHS GERPYRCPDC NKSFSQAANL TAHVRTHTGQ
     KPFRCPICDR RFSQSSSVTT HMRTHSGERP YRCSSCKKSF SDSSTLTKHL RIHSGEKPYQ
     CKLCLLRFSQ SGNLNRHMRV HGNNANGSGA GGGSGNGSGN GSGSGANGSA GAGSGLIT