GLB1L_MACFA
ID GLB1L_MACFA Reviewed; 654 AA.
AC Q95LV1; Q4R748; Q95LY1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Beta-galactosidase-1-like protein;
DE EC=3.2.1.-;
DE Flags: Precursor;
GN Name=GLB1L; ORFNames=QtsA-15875, QtsA-16327, QtsA-17830;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RA Hashimoto K., Osada N., Hida M., Kusuda J., Tanuma R., Hirai M., Terao K.,
RA Sugano S.;
RT "Isolation of novel full-length cDNA clones from macaque testis cDNA
RT libraries.";
RL Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 106-654.
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probable glycosyl hydrolase. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE01075.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB071060; BAB64453.1; -; mRNA.
DR EMBL; AB071090; BAB64484.1; -; mRNA.
DR EMBL; AB168978; BAE01075.1; ALT_INIT; mRNA.
DR RefSeq; NP_001271478.1; NM_001284549.1.
DR RefSeq; XP_005574408.1; XM_005574351.2.
DR RefSeq; XP_015287616.1; XM_015432130.1.
DR AlphaFoldDB; Q95LV1; -.
DR SMR; Q95LV1; -.
DR STRING; 9541.XP_005574408.1; -.
DR CAZy; GH35; Glycoside Hydrolase Family 35.
DR Ensembl; ENSMFAT00000009100; ENSMFAP00000034869; ENSMFAG00000003895.
DR GeneID; 102141964; -.
DR KEGG; mcf:102141964; -.
DR CTD; 79411; -.
DR VEuPathDB; HostDB:ENSMFAG00000003895; -.
DR eggNOG; KOG0496; Eukaryota.
DR GeneTree; ENSGT00950000182942; -.
DR OMA; GSYGACD; -.
DR OrthoDB; 179316at2759; -.
DR Proteomes; UP000233100; Chromosome 12.
DR Bgee; ENSMFAG00000003895; Expressed in liver and 13 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR InterPro; IPR026283; B-gal_1-like.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR23421; PTHR23421; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PIRSF; PIRSF006336; B-gal; 1.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF51445; SSF51445; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Glycosidase; Hydrolase; Reference proteome; Secreted; Signal.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..654
FT /note="Beta-galactosidase-1-like protein"
FT /id="PRO_0000313605"
FT ACT_SITE 186
FT /note="Proton donor"
FT /evidence="ECO:0000255"
FT ACT_SITE 264
FT /note="Nucleophile"
FT /evidence="ECO:0000255"
FT CARBOHYD 97
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 243
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 33
FT /note="D -> N (in Ref. 1; BAB64453)"
FT /evidence="ECO:0000305"
FT CONFLICT 627
FT /note="T -> A (in Ref. 1; BAB64453)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 654 AA; 74113 MW; E0815FB08856919E CRC64;
MAPKKPSCLR SLLLPLSLTL LLPQADTRSF IVDRDHDRFL LDGAPFRYVS GSLHYFRVPR
VLWADRLLKM RWSGLNAIQF YVPWNYHEPQ PGVYNFNGSR DLIAFLNEAA LANLLVILRP
GPYICAEWEM GGLPSWLLRK PEIRLRTSDP DFLAAVDSWF KVLLPKIYPW LYHNGGNIIS
IQVENEYGSY GACDFSYMRH LAGLFRALLG EKILLFTTDG PEGLKCGSLQ GLYTTVDFGP
ADNMTKIFTL LRKYEPHGPL VNSEYYTGWL DYWGQNHSTR SVSAVTKGLE NMLKLGASVN
MYMFHGGTNF GYWNGADKKG RFLSITTSYD YDAPISEAGD PTPKLFALRD VISKFQEVPL
GPLPPPSPKM MVGPLTLHLV GHLLAFLDLL CPSGPIRSIL PMTFEAVKQD RGFMLYRTYM
THTIFEPTPF WVPNNGVHDR AYVMVDGVFQ GVLERNMRDK LFLMGKVGSK LDILVENMGR
LSFGSNSSDF KGLLEPPILG QTILTQWMMF PLKIDNLVKW WFLLQLPKWP YPQAPSGPTF
YSKTFPILGS VGDTFLHLPG WTKGQVWING FNLGRYWTKR GPQQTLYVPR FLLFPRGALN
KITLLELENV PLQPQVQFLD KPILNSTSTL HRTHINSLSA DTLSASEPME LSGH
