ID   GLB1_ARTSX              Reviewed;         194 AA.
AC   P19363;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Extracellular globin-E1;
DE   Flags: Fragment;
OS   Artemia sp. (Brine shrimp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC   Anostraca; Artemiidae; Artemia; unclassified Artemia.
OX   NCBI_TaxID=6662;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=2078554;
RA   Manning A.M., Powell R.J., Trotman C.N., Tate W.P.;
RT   "Developmental expression and cDNA cloning of globin genes from the brine
RT   shrimp, Artemia.";
RL   New Biol. 2:77-83(1990).
RN   [2]
RP   PROTEIN SEQUENCE OF 48-147.
RX   PubMed=3350809; DOI=10.1016/s0021-9258(18)68836-2;
RA   Moens L., van Hauwaert M.-L., de Smet K., Geelen D., Verpooten G.,
RA   van Beeumen J., Wodak S., Alard P., Trotman C.;
RT   "A structural domain of the covalent polymer globin chains of artemia.
RT   Interpretation of amino acid sequence data.";
RL   J. Biol. Chem. 263:4679-4685(1988).
CC   -!- SUBUNIT: Artemia hemoglobin is a dimer of two similar sized subunits.
CC       Each subunit represents a globin chain which exists in two forms (alpha
CC       and beta), thus making possible three different phenotypes (HB1,
CC       alpha(2), HB2, alpha/beta, HB3, beta(2)). The globin chain is a polymer
CC       of eight heme-binding covalently linked domains.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A28141; A28141.
DR   AlphaFoldDB; P19363; -.
DR   SMR; P19363; -.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd01040; Mb-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR044399; Mb-like_M.
DR   Pfam; PF00042; Globin; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           <1..>194
FT                   /note="Extracellular globin-E1"
FT                   /id="PRO_0000052523"
FT   REGION          54..>194
FT                   /note="Globin"
FT   BINDING         150
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   NON_TER         1
FT   NON_TER         194
SQ   SEQUENCE   194 AA;  21935 MW;  6E956BA40FF7FA0B CRC64;
     DISHFQNFRV TLLEYLTENG MNGAQKASWN KAFDAFEKYI IMGLSSLERV DPITGLSGLE
     KNAILDTWGK VRGNLQEVGK ATFGKLFAAH PEYQQMFRFF QGVQLAFLVQ SPKFAAHTQR
     VVSALDQTLL ALNRPSDQFV YMIKELGLDH INRGTDRSFV EYLKESLGDS VDEFTVQSFG
     EVIVNFLNEG LRQA