ID   GLB1_LUMTE              Reviewed;         142 AA.
AC   P08924;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Extracellular globin-1;
DE   AltName: Full=Erythrocruorin;
DE   AltName: Full=Globin D;
DE   AltName: Full=Globin I;
OS   Lumbricus terrestris (Common earthworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Oligochaeta; Crassiclitellata; Lumbricina; Lumbricidae; Lumbricinae;
OC   Lumbricus.
OX   NCBI_TaxID=6398;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=3546301; DOI=10.1016/s0021-9258(18)61478-4;
RA   Shishikura F., Snow J.W., Gotoh T., Vinogradov S.N., Walz D.A.;
RT   "Amino acid sequence of the monomer subunit of the extracellular hemoglobin
RT   of Lumbricus terrestris.";
RL   J. Biol. Chem. 262:3123-3131(1987).
CC   -!- SUBUNIT: The extracellular hemoglobin of the earthworm consists of 12
CC       subunits that have a hexagonal bilayer structure with a molecular
CC       weight near 3.8 million. Each one-twelfth subunit is composed primarily
CC       of disulfide linked trimers (chains A, B, and C) and monomers (chain
CC       D).
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A29134; A29134.
DR   AlphaFoldDB; P08924; -.
DR   SMR; P08924; -.
DR   DIP; DIP-29125N; -.
DR   IntAct; P08924; 7.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd01040; Mb-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR014610; Haemoglobin_extracell.
DR   InterPro; IPR044399; Mb-like_M.
DR   Pfam; PF00042; Globin; 1.
DR   PIRSF; PIRSF036517; Ext_hemo; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Heme; Iron; Metal-binding;
KW   Oxygen transport; Transport.
FT   CHAIN           1..142
FT                   /note="Extracellular globin-1"
FT                   /id="PRO_0000052506"
FT   BINDING         94
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   DISULFID        2..131
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   142 AA;  16130 MW;  87BE8C74D1BBF1BE CRC64;
     ECLVTEGLKV KLQWASAFGH AHQRVAFGLE LWKGILREHP EIKAPFSRVR GDNIYSPQFG
     AHSQRVLSGL DITISMLDTP DMLAAQLAHL KVQHVERNLK PEFFDIFLKH LLHVLGDRLG
     THFDFGAWHD CVDQIIDGIK DI