ID   GLB1_METHI              Reviewed;         140 AA.
AC   P83122;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Extracellular globin-1;
DE   AltName: Full=Erythrocruorin;
DE   AltName: Full=Globin I;
OS   Metaphire hilgendorfi (Earthworm) (Pheretima hilgendorfi).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Oligochaeta; Crassiclitellata; Megascolecida; Megascolecidae; Metaphire.
OX   NCBI_TaxID=506675;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBUNIT, AND DISULFIDE BOND.
RC   TISSUE=Blood;
RX   PubMed=8940909; DOI=10.2108/zsj.13.551;
RA   Shishikura F.;
RT   "Amino acid sequence of the monomer subunit of the extracellular hemoglobin
RT   of the earthworm, Pheretima hilgendorfi.";
RL   Zool. Sci. 13:551-558(1996).
CC   -!- SUBUNIT: The giant hemoglobins of worms are formed of a monomeric
CC       subunit and a disulfide-bonded trimer. This subunit is monomeric.
CC       {ECO:0000269|PubMed:8940909}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   AlphaFoldDB; P83122; -.
DR   SMR; P83122; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd01040; Mb-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR014610; Haemoglobin_extracell.
DR   InterPro; IPR044399; Mb-like_M.
DR   Pfam; PF00042; Globin; 1.
DR   PIRSF; PIRSF036517; Ext_hemo; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Heme; Iron; Metal-binding;
KW   Oxygen transport; Secreted; Transport.
FT   CHAIN           1..140
FT                   /note="Extracellular globin-1"
FT                   /id="PRO_0000052507"
FT   BINDING         93
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   DISULFID        2..130
FT                   /evidence="ECO:0000269|PubMed:8940909"
SQ   SEQUENCE   140 AA;  16080 MW;  B1B509FBDFF9BAF5 CRC64;
     ECDVLERFKV KHQWQTVFSE AHRTEFSLHF WKEFLHDHPS LVELFTRVNG ANIYSPEFQA
     HGIRVLAGLD SVIGVLDEIP TLTVQLAHLK AQHTERGTKP EYFDLFGKHL ASHLGDELGT
     HFDYAAFRDC YDFIASGIKP