ID   GLB2_NIPBR              Reviewed;         154 AA.
AC   P51535;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Myoglobin;
DE   AltName: Full=Globin, body wall isoform;
GN   Name=GLBB;
OS   Nippostrongylus brasiliensis (Rat hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Trichostrongyloidea; Heligmonellidae; Nippostrongylinae; Nippostrongylus.
OX   NCBI_TaxID=27835;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7891734; DOI=10.1016/0166-6851(94)00127-8;
RA   Blaxter M.L., Ingram L., Tweedie S.;
RT   "Sequence, expression and evolution of the globins of the parasitic
RT   nematode Nippostrongylus brasiliensis.";
RL   Mol. Biochem. Parasitol. 68:1-14(1994).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: First expressed upon invasion of the mammalian
CC       host.
CC   -!- MISCELLANEOUS: The globins of the nematode parasite N.brasiliensis have
CC       oxygen affinities 100-fold higher than the rodent host's hemoglobins.
CC       Two isoforms are found, one located in the cuticle, and the other in
CC       the body of the nematode.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; L20895; AAA65539.1; -; mRNA.
DR   AlphaFoldDB; P51535; -.
DR   SMR; P51535; -.
DR   WBParaSite; NBR_0000844701-mRNA-1; NBR_0000844701-mRNA-1; NBR_0000844701.
DR   OMA; HINRHAA; -.
DR   Proteomes; UP000038043; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd01040; Mb-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR012085; Globin_nematode.
DR   InterPro; IPR044399; Mb-like_M.
DR   Pfam; PF00042; Globin; 1.
DR   PIRSF; PIRSF002026; Nematode_globin; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Heme; Iron; Metal-binding; Oxygen transport; Transport.
FT   CHAIN           1..154
FT                   /note="Myoglobin"
FT                   /id="PRO_0000052461"
FT   BINDING         96
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ   SEQUENCE   154 AA;  17363 MW;  76FD023645C4F2E1 CRC64;
     MADVKKNCLA SLSLAPISKA QQAQVGKDFY KFFFTNHPDL RKYFKGAENF TADDVQKSDR
     FEKLGSGLLL SVHILANTFD NEDVFRAFCR ETIDRHVGRG LDPALWKAFW SVWVAFLESK
     GGVSGDQKAA WDKLGTVFND ECQHQLAKHG LPHL