ID   GLB3_LAMSP              Reviewed;         144 AA.
AC   P15469;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Giant hemoglobin AIII chain;
OS   Lamellibrachia sp. (Deep-sea giant tube worm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC   Sedentaria; Canalipalpata; Sabellida; Siboglinidae; Lamellibrachia;
OC   unclassified Lamellibrachia.
OX   NCBI_TaxID=6424;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2310374; DOI=10.1042/bj2660221;
RA   Suzuki T., Takagi T., Ohta S.;
RT   "Primary structure of a constituent polypeptide chain (AIII) of the giant
RT   haemoglobin from the deep-sea tube worm Lamellibrachia. A possible H2S-
RT   binding site.";
RL   Biochem. J. 266:221-225(1990).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-24.
RX   PubMed=3202832;
RA   Suzuki T., Takagi T., Ohta S.;
RT   "N-terminal amino acid sequence of the deep-sea tube worm haemoglobin
RT   remarkably resembles that of annelid haemoglobin.";
RL   Biochem. J. 255:541-545(1988).
CC   -!- SUBUNIT: Giant hemoglobin is composed of four heme-containing chains
CC       (AI to AIV), and two linker chains (AV and AVI).
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; S01815; S01815.
DR   PIR; S08284; S08284.
DR   AlphaFoldDB; P15469; -.
DR   SMR; P15469; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd01040; Mb-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR002336; Erythrocruorin.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR014610; Haemoglobin_extracell.
DR   InterPro; IPR044399; Mb-like_M.
DR   Pfam; PF00042; Globin; 1.
DR   PIRSF; PIRSF036517; Ext_hemo; 1.
DR   PRINTS; PR00611; ERYTHCRUORIN.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   CHAIN           1..144
FT                   /note="Giant hemoglobin AIII chain"
FT                   /id="PRO_0000052521"
FT   BINDING         95
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ   SEQUENCE   144 AA;  16004 MW;  036CC2E9B1EF7E69 CRC64;
     YECGPLQRLK VKRQWAEAYG SGNDREEFGH FIWTHVFKDA PSARDLFKRV RGDNIHTPAF
     RAHATRVLGG LDMCIALLDD EGVLNTQLAH LASQHSSRGV SAAQYDVVEH SVMMGVEHEI
     GQNVFDKDAW QACLDVITGG IQGN