GLB4_CHITH
ID GLB4_CHITH Reviewed; 151 AA.
AC P02230;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1988, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Globin CTT-IV;
DE Flags: Precursor;
GN Name=D;
GN and
GN Name=D';
GN and
GN Name=C;
GN and
GN Name=C';
OS Chironomus thummi thummi (Midge).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC Chironominae; Chironomus.
OX NCBI_TaxID=7155;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3678833; DOI=10.1016/0378-1119(87)90156-9;
RA Antoine M., Erbil C., Muench E., Schnell S., Niessing J.;
RT "Genomic organization and primary structure of five homologous pairs of
RT intron-less genes encoding secretory globins from the insect Chironomus
RT thummi thummi.";
RL Gene 56:41-51(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Antoine M., Niessing J.;
RT "Intron-less globin genes in the insect Chironomus thummi thummi.";
RL Nature 310:795-798(1984).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Hankeln T., Amid C., Weich B., Schmidt E.R.;
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PROTEIN SEQUENCE OF 16-151.
RX PubMed=7250903; DOI=10.1515/bchm2.1981.362.1.539;
RA Pfletschinger J., Plagens H., Braunitzer G.;
RT "Hemoglobins, XL. Sequence analysis of the monomeric hemoglobin CTT IV
RT (erythrocruorin) of Chironomus thummi thummi, Diptera.";
RL Hoppe-Seyler's Z. Physiol. Chem. 362:539-547(1981).
CC -!- SUBUNIT: Monomer.
CC -!- MISCELLANEOUS: There are at least 12 different components in Midge
CC globin.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; X00920; CAA25438.1; -; Genomic_DNA.
DR EMBL; M17602; AAA28251.1; -; Genomic_DNA.
DR EMBL; M17693; AAA28256.1; -; Genomic_DNA.
DR EMBL; M17603; AAA28252.1; -; Genomic_DNA.
DR EMBL; M17694; AAA28257.1; -; Genomic_DNA.
DR EMBL; Y10622; CAA71641.1; -; Genomic_DNA.
DR EMBL; Y10622; CAA71642.1; -; Genomic_DNA.
DR PIR; A21808; GGICE4.
DR AlphaFoldDB; P02230; -.
DR SMR; P02230; -.
DR Allergome; 201; Chi t 1.
DR Allergome; 203; Chi t 1.0201.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd01040; Mb-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR002336; Erythrocruorin.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR044399; Mb-like_M.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00611; ERYTHCRUORIN.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Signal; Transport.
FT SIGNAL 1..15
FT /evidence="ECO:0000269|PubMed:7250903"
FT CHAIN 16..151
FT /note="Globin CTT-IV"
FT /id="PRO_0000011191"
FT BINDING 102
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT VARIANT 3
FT /note="L -> F (in C and C')"
SQ SEQUENCE 151 AA; 15935 MW; 7D5CA0B3554D01AF CRC64;
MKLLILALCF AAASALTADQ ISTVQSSFAG VKGDAVGILY AVFKADPSIQ AKFTQFAGKD
LDSIKGSADF SAHANKIVGF FSKIIGDLPN IDGDVTTFVA SHTPRGVTHD QLNNFRAGFV
SYMKAHTDFA GAEAAWGATL DAFFGMVFAK M
