GLB63_ORYSJ
ID GLB63_ORYSJ Reviewed; 562 AA.
AC Q75GX9; C7J006; Q75GX8;
DT 08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=63 kDa globulin-like protein {ECO:0000305};
DE AltName: Allergen=Ory s GLP63;
DE Flags: Precursor;
GN OrderedLocusNames=Os03g0663800 {ECO:0000312|EMBL:BAS85618.1},
GN LOC_Os03g46100 {ECO:0000312|EMBL:ABF98039.1};
GN ORFNames=OSJNBa0034D21.12 {ECO:0000312|EMBL:AAS07324.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16109971; DOI=10.1101/gr.3869505;
RG The rice chromosome 3 sequencing consortium;
RA Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA Jin W., Lee H.R., Jiang J., Jackson S.;
RT "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT and diverged grass species.";
RL Genome Res. 15:1284-1291(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Nipponbare;
RX PubMed=12869764; DOI=10.1126/science.1081288;
RG The rice full-length cDNA consortium;
RT "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT japonica rice.";
RL Science 301:376-379(2003).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND ALLERGEN.
RX PubMed=21300107; DOI=10.1016/j.yrtph.2011.01.008;
RA Satoh R., Nakamura R., Komatsu A., Oshima M., Teshima R.;
RT "Proteomic analysis of known and candidate rice allergens between non-
RT transgenic and transgenic plants.";
RL Regul. Toxicol. Pharmacol. 59:437-444(2011).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND ALLERGEN.
RX PubMed=23763241; DOI=10.1021/pr4002146;
RA Kurokawa S., Nakamura R., Mejima M., Kozuka-Hata H., Kuroda M.,
RA Takeyama N., Oyama M., Satoh S., Kiyono H., Masumura T., Teshima R.,
RA Yuki Y.;
RT "MucoRice-cholera toxin B-subunit, a rice-based oral cholera vaccine, down-
RT regulates the expression of alpha-amylase/trypsin inhibitor-like protein
RT family as major rice allergens.";
RL J. Proteome Res. 12:3372-3382(2013).
CC -!- FUNCTION: Seed storage protein. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q75GX9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q75GX9-2; Sequence=VSP_058381;
CC -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
CC {ECO:0000269|PubMed:21300107, ECO:0000269|PubMed:23763241}.
CC -!- SIMILARITY: Belongs to the 7S seed storage protein family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAH92302.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC137991; AAS07324.1; -; Genomic_DNA.
DR EMBL; AC137991; AAS07325.1; -; Genomic_DNA.
DR EMBL; DP000009; ABF98039.1; -; Genomic_DNA.
DR EMBL; DP000009; ABF98041.1; -; Genomic_DNA.
DR EMBL; AP008209; BAH92302.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AP014959; BAS85618.1; -; Genomic_DNA.
DR EMBL; AK105347; BAG97202.1; -; mRNA.
DR AlphaFoldDB; Q75GX9; -.
DR SMR; Q75GX9; -.
DR STRING; 4530.OS03T0663800-01; -.
DR Allergome; 9526; Ory s GLP63.
DR PRIDE; Q75GX9; -.
DR EnsemblPlants; Os03t0663800-01; Os03t0663800-01; Os03g0663800. [Q75GX9-2]
DR Gramene; Os03t0663800-01; Os03t0663800-01; Os03g0663800. [Q75GX9-2]
DR eggNOG; ENOG502QQEP; Eukaryota.
DR InParanoid; Q75GX9; -.
DR OMA; HEMKKER; -.
DR Proteomes; UP000000763; Chromosome 3.
DR Proteomes; UP000059680; Chromosome 3.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0019863; F:IgE binding; IDA:UniProtKB.
DR GO; GO:0045735; F:nutrient reservoir activity; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.10; -; 2.
DR InterPro; IPR006045; Cupin_1.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR Pfam; PF00190; Cupin_1; 2.
DR SMART; SM00835; Cupin_1; 2.
DR SUPFAM; SSF51182; SSF51182; 1.
PE 1: Evidence at protein level;
KW Allergen; Alternative splicing; Glycoprotein; Reference proteome; Secreted;
KW Seed storage protein; Signal; Storage protein.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..562
FT /note="63 kDa globulin-like protein"
FT /id="PRO_5007212835"
FT DOMAIN 106..264
FT /note="Cupin type-1 1"
FT /evidence="ECO:0000255"
FT DOMAIN 312..507
FT /note="Cupin type-1 2"
FT /evidence="ECO:0000255"
FT REGION 63..103
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..412
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 524..550
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 350
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT VAR_SEQ 231..562
FT /note="FFFAPGGRNPESFLSSFSKGVQRAAFKISEEKLEKLLGKQDKGVIIRASEEQ
FT VRELRRHASEGGHGPHWPLPPFGESSRGPFNILEQRPRFANRHGRLYEADARSFHDLAE
FT HDIRVAVVNITAGSMNAPFYNTRSVKVAYVLDGEGEAEIVCPHLSRGGRGGESEERRRE
FT RGKGKWREEEEEEEEQQKGQEEEEEEQVGQGYETIRARLSRGTVFVVPSGHPIVVTSSR
FT DSTLQIVCFDVHANNNERMYLAGMNSVLKKLDPQAKELAFAASAREVDELLNAQQESAF
FT LAGPEKSGRRGEESEDEDRRRRRSHRGRGDEAVETLLRMAAAAV -> ARTRSIKSLFI
FT NSNQLSTHK (in isoform 2)"
FT /id="VSP_058381"
SQ SEQUENCE 562 AA; 63428 MW; DF7AF19AFC5108BC CRC64;
MATRARATIL LLLAAVLFAA AAAASGEDRR RETSLRRCLQ RCEQDRPPYE RARCVQECKD
QQQQQQERRR EHGGHDDDRR DRDRRGEGSS EEEDEGRERG SRRRPYVFGR RSFRQVVRSD
QGSVRLLPPF HQASSLLRGI KNYRVAVLEA NPRSFVMPTH TDAHCICYVA QGEGVVAIIE
NGEKWSYAIR QGDVFVAPAG TINYLANTDG RRKLIVTKIL HTISVPGQIQ FFFAPGGRNP
ESFLSSFSKG VQRAAFKISE EKLEKLLGKQ DKGVIIRASE EQVRELRRHA SEGGHGPHWP
LPPFGESSRG PFNILEQRPR FANRHGRLYE ADARSFHDLA EHDIRVAVVN ITAGSMNAPF
YNTRSVKVAY VLDGEGEAEI VCPHLSRGGR GGESEERRRE RGKGKWREEE EEEEEQQKGQ
EEEEEEQVGQ GYETIRARLS RGTVFVVPSG HPIVVTSSRD STLQIVCFDV HANNNERMYL
AGMNSVLKKL DPQAKELAFA ASAREVDELL NAQQESAFLA GPEKSGRRGE ESEDEDRRRR
RSHRGRGDEA VETLLRMAAA AV
