GLB76_CHITH
ID GLB76_CHITH Reviewed; 161 AA.
AC P12549; P02225;
DT 01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1989, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Globin CTT-VIIB-6;
DE Flags: Precursor;
GN Name=CTT-7B6;
OS Chironomus thummi thummi (Midge).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC Chironominae; Chironomus.
OX NCBI_TaxID=7155;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Larva;
RX PubMed=2852146; DOI=10.1016/0378-1119(88)90381-2;
RA Trewitt P.M., Saffarini D.A., Bergtrom G.;
RT "Multiple clustered genes of the haemoglobin VIIB subfamily of Chironomus
RT thummi thummi (Diptera).";
RL Gene 69:91-100(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Larva;
RX PubMed=7563117; DOI=10.1007/bf01215178;
RA Trewitt P.M., Luhm R.A., Samad F., Ramakrishnan S., Kao W.-Y., Bergtrom G.;
RT "Molecular evolutionary analysis of the YWVZ/7B globin gene cluster of the
RT insect Chironomus thummi.";
RL J. Mol. Evol. 41:313-328(1995).
RN [3]
RP PROTEIN SEQUENCE OF 17-161 (MIXTURE OF ISOZYMES).
RX PubMed=422121;
RA Sladic-Simic D., Kleinschmidt T., Braunitzer G.;
RT "Hemoglobins, XXVI. Analysis of the primary structure of the dimeric insect
RT haemoglobin CTT VIIB (Erythrocruorin) from Chironomus thummi thummi,
RT Diptera.";
RL Hoppe-Seyler's Z. Physiol. Chem. 360:115-124(1979).
CC -!- SUBUNIT: Homodimer.
CC -!- MISCELLANEOUS: There are at least 12 different components in Midge
CC globin.
CC -!- MISCELLANEOUS: There are at least nine genes for VIIB variants.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; U07703; AAA85486.1; -; Genomic_DNA.
DR PIR; A02547; GGICE8.
DR PIR; A30477; A30477.
DR AlphaFoldDB; P12549; -.
DR SMR; P12549; -.
DR Allergome; 207; Chi t 3.
DR Allergome; 209; Chi t 3.0702.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd01040; Mb-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR002336; Erythrocruorin.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR044399; Mb-like_M.
DR Pfam; PF00042; Globin; 1.
DR PRINTS; PR00611; ERYTHCRUORIN.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Signal; Transport.
FT SIGNAL 1..16
FT /evidence="ECO:0000269|PubMed:422121"
FT CHAIN 17..161
FT /note="Globin CTT-VIIB-6"
FT /id="PRO_0000011199"
FT BINDING 76
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="distal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT BINDING 111
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ SEQUENCE 161 AA; 16959 MW; EA1BBC954BA432EF CRC64;
MKFFAVLALC IVGAIASPLT ADEASLVQSS WKAVSHNEVE ILAAVFAAYP DIQNKFSQFA
GKDLASIKDT GAFATHATRI VSFLSEVIAL SGNDSNAAAV NSLVSKLGDD HKARGVSAAQ
FGEFRTALVA YLQANVSWGD NVAAAWNKAL DNTFAIVVPR L
