ID   GLB7A_CHITH             Reviewed;         161 AA.
AC   P02226; O02368;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 2.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Globin CTT-VIIA;
DE   Flags: Precursor;
GN   Name=ctt-7A.1;
OS   Chironomus thummi thummi (Midge).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC   Chironominae; Chironomus.
OX   NCBI_TaxID=7155;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8006991; DOI=10.1007/bf00176086;
RA   Kao W.-Y., Trewitt P.M., Bergtrom G.;
RT   "Intron-containing globin genes in the insect Chironomus thummi.";
RL   J. Mol. Evol. 38:241-249(1994).
RN   [2]
RP   PROTEIN SEQUENCE OF 17-161.
RX   PubMed=7399413;
RA   Kleinschmidt T., Braunitzer G.;
RT   "Hemoglobins, XXXII. Analysis of the primary structure of the monomeric
RT   hemoglobin CTT VIIA (erythrocruorin) or Chironomus thummi thummi,
RT   Diptera.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 361:933-942(1980).
CC   -!- SUBUNIT: Homodimer.
CC   -!- MISCELLANEOUS: There are at least 12 different components in Midge
CC       globin.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; AF001292; AAB58930.1; -; Genomic_DNA.
DR   PIR; A02548; GGICE7.
DR   AlphaFoldDB; P02226; -.
DR   SMR; P02226; -.
DR   Allergome; 207; Chi t 3.
DR   Allergome; 210; Chi t 3.0301.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd01040; Mb-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR002336; Erythrocruorin.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR044399; Mb-like_M.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00611; ERYTHCRUORIN.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Signal; Transport.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000269|PubMed:7399413"
FT   CHAIN           17..161
FT                   /note="Globin CTT-VIIA"
FT                   /id="PRO_0000011193"
FT   BINDING         76
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         111
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   CONFLICT        17
FT                   /note="S -> A (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        25
FT                   /note="A -> S (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   161 AA;  16830 MW;  4C3A620317025D30 CRC64;
     MKFFAVLALC IVGAIASPLS ADQAALVKST WAQVRNSEVE ILAAVFTAYP DIQARFPQFA
     GKDVASIKDT GAFATHAGRI VGFVSEIIAL IGNESNAPAV QTLVGQLAAS HKARGISQAQ
     FNEFRAGLVS YVSSNVAWNA AAESAWTAGL DNIFGLLFAA L