ID   GLBBP_PSEAE             Reviewed;         311 AA.
AC   Q9HXC4;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Glycine-betaine-binding protein {ECO:0000305};
DE   Flags: Precursor;
GN   OrderedLocusNames=PA3889 {ECO:0000312|EMBL:AAG07276.1};
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2]
RP   FUNCTION AS A BINDING PROTEIN.
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=31627455; DOI=10.3390/ijms20205156;
RA   Fernandez M., Rico-Jimenez M., Ortega A., Daddaoua A., Garcia Garcia A.I.,
RA   Martin-Mora D., Torres N.M., Tajuelo A., Matilla M.A., Krell T.;
RT   "Determination of Ligand Profiles for Pseudomonas aeruginosa Solute Binding
RT   Proteins.";
RL   Int. J. Mol. Sci. 20:5156-5156(2019).
CC   -!- FUNCTION: Binds glycine-betaine. {ECO:0000269|PubMed:31627455}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the OsmX family. {ECO:0000305}.
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DR   EMBL; AE004091; AAG07276.1; -; Genomic_DNA.
DR   PIR; E83159; E83159.
DR   RefSeq; NP_252578.1; NC_002516.2.
DR   RefSeq; WP_003113769.1; NZ_QZGE01000001.1.
DR   AlphaFoldDB; Q9HXC4; -.
DR   SMR; Q9HXC4; -.
DR   STRING; 287.DR97_3978; -.
DR   PaxDb; Q9HXC4; -.
DR   PRIDE; Q9HXC4; -.
DR   DNASU; 878805; -.
DR   EnsemblBacteria; AAG07276; AAG07276; PA3889.
DR   GeneID; 878805; -.
DR   KEGG; pae:PA3889; -.
DR   PATRIC; fig|208964.12.peg.4073; -.
DR   PseudoCAP; PA3889; -.
DR   HOGENOM; CLU_038355_1_0_6; -.
DR   InParanoid; Q9HXC4; -.
DR   OMA; APMNNTY; -.
DR   PhylomeDB; Q9HXC4; -.
DR   BioCyc; PAER208964:G1FZ6-3962-MON; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0043190; C:ATP-binding cassette (ABC) transporter complex; ISS:PseudoCAP.
DR   GO; GO:0042597; C:periplasmic space; ISS:PseudoCAP.
DR   GO; GO:0015226; F:carnitine transmembrane transporter activity; ISS:PseudoCAP.
DR   GO; GO:0015838; P:amino-acid betaine transport; ISS:PseudoCAP.
DR   GO; GO:0071475; P:cellular hyperosmotic salinity response; ISS:PseudoCAP.
DR   GO; GO:0031460; P:glycine betaine transport; ISS:PseudoCAP.
DR   InterPro; IPR007210; ABC_Gly_betaine_transp_sub-bd.
DR   Pfam; PF04069; OpuAC; 1.
PE   1: Evidence at protein level;
KW   Periplasm; Reference proteome; Signal; Transport.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..311
FT                   /note="Glycine-betaine-binding protein"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_5004326868"
SQ   SEQUENCE   311 AA;  34722 MW;  0E91775232D3A7CC CRC64;
     MNRLIRSLCL ACAGLFAAGL AQAETLRIGG KTFTEQRILT AITAQFLQKR GYDVTVTTGL
     GSTLARAAQE SGQLDIVWEY TGSSLIVYNH IDEKLDAAAS YRRVKQLDEA QGLVWLKPTR
     FNNTYALAMP EEQAEHLGIQ SVSDLARVLA EQQEAEPGST HLFAMDPEFA GRPDGLGPMS
     ELYGLHFTRN DIRQMDAGLV YTALKNRQVF LGLVYTTDGR LKDFKLRVLK DDKQYFPFYN
     AAPVVRKEVM QRHPEFATLF DPIIERLDDA TMQALNARVD IEQQTPQKVA ADFLREHHLL
     DDGQAGQGGS Q