ID   GLBC_NIPBR              Reviewed;         173 AA.
AC   P51536;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Globin, cuticular isoform;
DE   Flags: Precursor;
GN   Name=GLBC;
OS   Nippostrongylus brasiliensis (Rat hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Trichostrongyloidea; Heligmonellidae; Nippostrongylinae; Nippostrongylus.
OX   NCBI_TaxID=27835;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX   PubMed=7891734; DOI=10.1016/0166-6851(94)00127-8;
RA   Blaxter M.L., Ingram L., Tweedie S.;
RT   "Sequence, expression and evolution of the globins of the parasitic
RT   nematode Nippostrongylus brasiliensis.";
RL   Mol. Biochem. Parasitol. 68:1-14(1994).
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed only by adult nematodes in the gut.
CC   -!- MISCELLANEOUS: The globins of the nematode parasite N.brasiliensis have
CC       oxygen affinities 100-fold higher than the rodent host's hemoglobins.
CC       Two isoforms are found, one located in the cuticle, and the other in
CC       the body of the nematode.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; L20896; AAA65540.1; -; mRNA.
DR   EMBL; L25872; AAA72047.1; -; Genomic_DNA.
DR   AlphaFoldDB; P51536; -.
DR   SMR; P51536; -.
DR   PRIDE; P51536; -.
DR   Proteomes; UP000038043; Genome assembly.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd01040; Mb-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR012085; Globin_nematode.
DR   InterPro; IPR044399; Mb-like_M.
DR   Pfam; PF00042; Globin; 1.
DR   PIRSF; PIRSF002026; Nematode_globin; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Secreted; Signal; Transport.
FT   SIGNAL          1..16
FT   CHAIN           17..173
FT                   /note="Globin, cuticular isoform"
FT                   /id="PRO_0000011186"
FT   BINDING         113
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
SQ   SEQUENCE   173 AA;  19696 MW;  75475A9288FFD9C1 CRC64;
     MLWFVAVCFA IASVSAMSPA DVKKHTVESM KAVPVGRDKA QNGIDFYKFF FTHHKDLRKF
     FKGAENFGAD DVQKSKRFEK QGTALLLAVH VLANVYDNQA VFHGFVRELM NRHEKRGVDP
     KLWKIFFDDV WVPFLESKGA KLSGDAKAAW KELNKNFNSE AQHQLEKLGL PHA