GLBH_CAEEL
ID GLBH_CAEEL Reviewed; 159 AA.
AC P30627; Q26332;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Globin-like protein;
GN Name=glb-1; Synonyms=cbg-1, glo; ORFNames=ZK637.13;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8325507; DOI=10.1016/0378-1119(93)90271-4;
RA Kloek A.P., Sherman D.R., Goldberg D.E.;
RT "Novel gene structure and evolutionary context of Caenorhabditis elegans
RT globin.";
RL Gene 129:215-221(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8401321;
RA Mansell J.B., Timms K., Tate W.P., Moens L., Trotman C.N.;
RT "Expression of a globin gene in Caenorhabditis elegans.";
RL Biochem. Mol. Biol. Int. 30:643-647(1993).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=1538779; DOI=10.1038/356037a0;
RA Sulston J., Du Z., Thomas K., Wilson R., Hillier L., Staden R.,
RA Halloran N., Green P., Thierry-Mieg J., Qiu L., Dear S., Coulson A.,
RA Craxton M., Durbin R., Berks M., Metzstein M., Hawkins T., Ainscough R.,
RA Waterston R.;
RT "The C. elegans genome sequencing project: a beginning.";
RL Nature 356:37-41(1992).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [5]
RP X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS), SUBUNIT, SUBCELLULAR LOCATION,
RP TISSUE SPECIFICITY, INDUCTION, AND IRON-BINDING SITE.
RX PubMed=20361867; DOI=10.1186/1471-2091-11-17;
RA Geuens E., Hoogewijs D., Nardini M., Vinck E., Pesce A., Kiger L., Fago A.,
RA Tilleman L., De Henau S., Marden M.C., Weber R.E., Van Doorslaer S.,
RA Vanfleteren J., Moens L., Bolognesi M., Dewilde S.;
RT "Globin-like proteins in Caenorhabditis elegans: in vivo localization,
RT ligand binding and structural properties.";
RL BMC Biochem. 11:17-17(2010).
CC -!- FUNCTION: May be a globin and may play a role in oxygen transport.
CC {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:20361867}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20361867}.
CC -!- TISSUE SPECIFICITY: Expressed mainly in a subset of neuronal cells and
CC in head muscular tissue. {ECO:0000269|PubMed:20361867}.
CC -!- INDUCTION: By hypoxia. {ECO:0000269|PubMed:20361867}.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-3 is the initiator.
CC {ECO:0000305}.
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DR EMBL; Z18264; CAA79148.1; -; mRNA.
DR EMBL; S66164; AAB28512.3; -; mRNA.
DR EMBL; Z11115; CAA77458.2; -; Genomic_DNA.
DR PIR; JC1516; JC1516.
DR PIR; T41748; T41748.
DR RefSeq; NP_498974.2; NM_066573.6.
DR PDB; 2WTG; X-ray; 1.50 A; A=1-159.
DR PDB; 2WTH; X-ray; 2.80 A; A/B=1-159.
DR PDBsum; 2WTG; -.
DR PDBsum; 2WTH; -.
DR AlphaFoldDB; P30627; -.
DR SMR; P30627; -.
DR BioGRID; 41462; 34.
DR STRING; 6239.ZK637.13.1; -.
DR World-2DPAGE; 0011:P30627; -.
DR EPD; P30627; -.
DR PaxDb; P30627; -.
DR PeptideAtlas; P30627; -.
DR EnsemblMetazoa; ZK637.13.1; ZK637.13.1; WBGene00014030.
DR GeneID; 176261; -.
DR KEGG; cel:CELE_ZK637.13; -.
DR CTD; 176261; -.
DR WormBase; ZK637.13; CE36418; WBGene00014030; glb-1.
DR eggNOG; ENOG502SFTY; Eukaryota.
DR HOGENOM; CLU_099979_0_0_1; -.
DR InParanoid; P30627; -.
DR OMA; DPALWMA; -.
DR OrthoDB; 1370559at2759; -.
DR EvolutionaryTrace; P30627; -.
DR PRO; PR:P30627; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00014030; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd01040; Mb-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR012085; Globin_nematode.
DR InterPro; IPR044399; Mb-like_M.
DR Pfam; PF00042; Globin; 1.
DR PIRSF; PIRSF002026; Nematode_globin; 1.
DR SUPFAM; SSF46458; SSF46458; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Heme; Iron; Metal-binding; Oxygen transport;
KW Reference proteome; Transport.
FT CHAIN 1..159
FT /note="Globin-like protein"
FT /id="PRO_0000052463"
FT BINDING 101
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="proximal binding residue"
FT HELIX 5..15
FT /evidence="ECO:0007829|PDB:2WTG"
FT HELIX 16..19
FT /evidence="ECO:0007829|PDB:2WTG"
FT HELIX 25..41
FT /evidence="ECO:0007829|PDB:2WTG"
FT HELIX 43..48
FT /evidence="ECO:0007829|PDB:2WTG"
FT TURN 50..54
FT /evidence="ECO:0007829|PDB:2WTH"
FT HELIX 57..61
FT /evidence="ECO:0007829|PDB:2WTG"
FT HELIX 64..83
FT /evidence="ECO:0007829|PDB:2WTG"
FT HELIX 87..101
FT /evidence="ECO:0007829|PDB:2WTG"
FT HELIX 102..104
FT /evidence="ECO:0007829|PDB:2WTG"
FT HELIX 110..122
FT /evidence="ECO:0007829|PDB:2WTG"
FT TURN 123..125
FT /evidence="ECO:0007829|PDB:2WTG"
FT HELIX 130..153
FT /evidence="ECO:0007829|PDB:2WTG"
SQ SEQUENCE 159 AA; 18501 MW; 0C2E473C56F59CFE CRC64;
MSMNRQEISD LCVKSLEGRM VGTEAQNIEN GNAFYRYFFT NFPDLRVYFK GAEKYTADDV
KKSERFDKQG QRILLACHLL ANVYTNEEVF KGYVRETINR HRIYKMDPAL WMAFFTVFTG
YLESVGCLND QQKAAWMALG KEFNAESQTH LKNSNLPHV
