GLBH_TRICO
ID GLBH_TRICO Reviewed; 173 AA.
AC P27613;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Globin-like host-protective antigen;
DE Flags: Precursor;
OS Trichostrongylus colubriformis (Black scour worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC Trichostrongyloidea; Trichostrongylidae; Trichostrongylus.
OX NCBI_TaxID=6319;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 16-37 AND 163-173.
RC STRAIN=McMaster;
RX PubMed=1542314; DOI=10.1016/0166-6851(92)90241-b;
RA Frenkel M.J., Dopheide T.A.A., Wagland B.M., Ward C.W.;
RT "The isolation, characterization and cloning of a globin-like, host-
RT protective antigen from the excretory-secretory products of
RT Trichostrongylus colubriformis.";
RL Mol. Biochem. Parasitol. 50:27-36(1992).
CC -!- FUNCTION: May be a globin and may play a role in oxygen transport.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space.
CC -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC ProRule:PRU00238}.
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DR EMBL; M63263; AAA30102.1; -; mRNA.
DR PIR; A45646; A45646.
DR AlphaFoldDB; P27613; -.
DR SMR; P27613; -.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd01040; Mb-like; 1.
DR Gene3D; 1.10.490.10; -; 1.
DR InterPro; IPR000971; Globin.
DR InterPro; IPR009050; Globin-like_sf.
DR InterPro; IPR012292; Globin/Proto.
DR InterPro; IPR012085; Globin_nematode.
DR InterPro; IPR044399; Mb-like_M.
DR Pfam; PF00042; Globin; 1.
DR PIRSF; PIRSF002026; Nematode_globin; 1.
DR SUPFAM; SSF46458; SSF46458; 1.
DR PROSITE; PS01033; GLOBIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW Secreted; Signal; Transport.
FT SIGNAL 1..15
FT /evidence="ECO:0000269|PubMed:1542314"
FT CHAIN 16..173
FT /note="Globin-like host-protective antigen"
FT /id="PRO_0000011187"
FT BINDING 114
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
FT VARIANT 126
FT /note="E -> D (in clone ADES3/2)"
FT VARIANT 129
FT /note="S -> G (in clone ADES3/2)"
SQ SEQUENCE 173 AA; 19989 MW; 74019C76C18BE6ED CRC64;
MRFLLLAAFV AYAYAKSDEE IRKDALSALD VVPLGSTPEK LENGREFYKY FFTNHQDLRK
YFKGAETFTA DDIAKSDRFK KLGNQLLLSV HLAADTYDNE MIFRAFVRDT IDRHVDRGLD
PKLWKEFWSI YQKFLESKGK TLSADQKAAF DAIGTRFNDE AQKQLAHHGL PHT
