GLBL2_HUMAN
ID GLBL2_HUMAN Reviewed; 636 AA.
AC Q8IW92; A6NCE6; Q6UX60; Q8NC62; Q8NCB3; Q8NCJ1; Q96HP3;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Beta-galactosidase-1-like protein 2;
DE EC=3.2.1.-;
DE Flags: Precursor;
GN Name=GLB1L2; ORFNames=MSTP014, UNQ210/PRO236;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 63-636.
RC TISSUE=Aorta;
RA Liu B., Zhao B., Wang X.Y., Liu Y.Q., Sheng H., Qin B.M., Zhang Q.,
RA Zheng W.Y., Xu H.S., Liu B.H., Lu H., Gong Q., Hui R.T.;
RT "Homo sapiens normal aorta mRNA MST114.";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC Q8IW92; Q9UQM7: CAMK2A; NbExp=3; IntAct=EBI-11954377, EBI-1383687;
CC Q8IW92; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11954377, EBI-3867333;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAQ13636.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAC11149.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY358497; AAQ88861.1; -; mRNA.
DR EMBL; AK074703; BAC11149.1; ALT_INIT; mRNA.
DR EMBL; AK074947; BAC11309.1; -; mRNA.
DR EMBL; AK074855; BAC11247.1; -; mRNA.
DR EMBL; AP003971; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471065; EAW67843.1; -; Genomic_DNA.
DR EMBL; BC008326; AAH08326.1; -; mRNA.
DR EMBL; BC040641; AAH40641.1; -; mRNA.
DR EMBL; AF173889; AAQ13636.1; ALT_INIT; mRNA.
DR CCDS; CCDS31724.1; -.
DR RefSeq; NP_612351.2; NM_138342.3.
DR RefSeq; XP_006719000.1; XM_006718937.1.
DR AlphaFoldDB; Q8IW92; -.
DR SMR; Q8IW92; -.
DR BioGRID; 124647; 82.
DR IntAct; Q8IW92; 22.
DR STRING; 9606.ENSP00000444628; -.
DR CAZy; GH35; Glycoside Hydrolase Family 35.
DR iPTMnet; Q8IW92; -.
DR PhosphoSitePlus; Q8IW92; -.
DR BioMuta; GLB1L2; -.
DR DMDM; 74728154; -.
DR EPD; Q8IW92; -.
DR jPOST; Q8IW92; -.
DR MassIVE; Q8IW92; -.
DR MaxQB; Q8IW92; -.
DR PaxDb; Q8IW92; -.
DR PeptideAtlas; Q8IW92; -.
DR PRIDE; Q8IW92; -.
DR ProteomicsDB; 70822; -.
DR Antibodypedia; 53678; 95 antibodies from 16 providers.
DR DNASU; 89944; -.
DR Ensembl; ENST00000339772.9; ENSP00000344659.6; ENSG00000149328.15.
DR Ensembl; ENST00000535456.7; ENSP00000444628.1; ENSG00000149328.15.
DR GeneID; 89944; -.
DR KEGG; hsa:89944; -.
DR MANE-Select; ENST00000535456.7; ENSP00000444628.1; NM_001370461.1; NP_001357390.1.
DR UCSC; uc001qhp.3; human.
DR CTD; 89944; -.
DR DisGeNET; 89944; -.
DR GeneCards; GLB1L2; -.
DR HGNC; HGNC:25129; GLB1L2.
DR HPA; ENSG00000149328; Tissue enriched (retina).
DR neXtProt; NX_Q8IW92; -.
DR OpenTargets; ENSG00000149328; -.
DR PharmGKB; PA162389761; -.
DR VEuPathDB; HostDB:ENSG00000149328; -.
DR eggNOG; KOG0496; Eukaryota.
DR GeneTree; ENSGT00950000182942; -.
DR HOGENOM; CLU_007853_7_2_1; -.
DR InParanoid; Q8IW92; -.
DR OMA; EMKPAFM; -.
DR OrthoDB; 179316at2759; -.
DR PhylomeDB; Q8IW92; -.
DR TreeFam; TF354299; -.
DR PathwayCommons; Q8IW92; -.
DR SignaLink; Q8IW92; -.
DR BioGRID-ORCS; 89944; 10 hits in 1074 CRISPR screens.
DR ChiTaRS; GLB1L2; human.
DR GenomeRNAi; 89944; -.
DR Pharos; Q8IW92; Tdark.
DR PRO; PR:Q8IW92; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8IW92; protein.
DR Bgee; ENSG00000149328; Expressed in right uterine tube and 115 other tissues.
DR ExpressionAtlas; Q8IW92; baseline and differential.
DR Genevisible; Q8IW92; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR GO; GO:0004565; F:beta-galactosidase activity; IBA:GO_Central.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR InterPro; IPR026283; B-gal_1-like.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR019801; Glyco_hydro_35_CS.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR23421; PTHR23421; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PIRSF; PIRSF006336; B-gal; 1.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF51445; SSF51445; 1.
DR PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE 1: Evidence at protein level;
KW Glycosidase; Hydrolase; Reference proteome; Secreted; Signal.
FT SIGNAL 1..32
FT /evidence="ECO:0000255"
FT CHAIN 33..636
FT /note="Beta-galactosidase-1-like protein 2"
FT /id="PRO_0000317513"
FT ACT_SITE 201
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT ACT_SITE 277
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT CONFLICT 50
FT /note="K -> M (in Ref. 2; BAC11309)"
FT /evidence="ECO:0000305"
FT CONFLICT 117
FT /note="L -> Q (in Ref. 2; BAC11309)"
FT /evidence="ECO:0000305"
FT CONFLICT 448
FT /note="H -> R (in Ref. 3; BAC11247)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 636 AA; 72079 MW; 3661AB67B0C99811 CRC64;
MTTWSLRRRP ARTLGLLLLV VLGFLVLRRL DWSTLVPLRL RHRQLGLQAK GWNFMLEDST
FWIFGGSIHY FRVPREYWRD RLLKMKACGL NTLTTYVPWN LHEPERGKFD FSGNLDLEAF
VLMAAEIGLW VILRPGPYIC SEMDLGGLPS WLLQDPGMRL RTTYKGFTEA VDLYFDHLMS
RVVPLQYKRG GPIIAVQVEN EYGSYNKDPA YMPYVKKALE DRGIVELLLT SDNKDGLSKG
IVQGVLATIN LQSTHELQLL TTFLFNVQGT QPKMVMEYWT GWFDSWGGPH NILDSSEVLK
TVSAIVDAGS SINLYMFHGG TNFGFMNGAM HFHDYKSDVT SYDYDAVLTE AGDYTAKYMK
LRDFFGSISG IPLPPPPDLL PKMPYEPLTP VLYLSLWDAL KYLGEPIKSE KPINMENLPV
NGGNGQSFGY ILYETSITSS GILSGHVHDR GQVFVNTVSI GFLDYKTTKI AVPLIQGYTV
LRILVENRGR VNYGENIDDQ RKGLIGNLYL NDSPLKNFRI YSLDMKKSFF QRFGLDKWSS
LPETPTLPAF FLGSLSISST PCDTFLKLEG WEKGVVFING QNLGRYWNIG PQKTLYLPGP
WLSSGINQVI VFEETMAGPA LQFTETPHLG RNQYIK
