GLBL3_MOUSE
ID GLBL3_MOUSE Reviewed; 649 AA.
AC A2RSQ1; Q9D5X3;
DT 03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Beta-galactosidase-1-like protein 3;
DE EC=3.2.1.-;
GN Name=Glb1l3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A2RSQ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A2RSQ1-2; Sequence=VSP_024289;
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family. {ECO:0000305}.
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DR EMBL; AK014852; BAB29584.1; -; mRNA.
DR EMBL; BC132200; AAI32201.1; -; mRNA.
DR EMBL; BC132202; AAI32203.1; -; mRNA.
DR RefSeq; NP_001106794.1; NM_001113323.1.
DR AlphaFoldDB; A2RSQ1; -.
DR SMR; A2RSQ1; -.
DR STRING; 10090.ENSMUSP00000034448; -.
DR CAZy; GH35; Glycoside Hydrolase Family 35.
DR iPTMnet; A2RSQ1; -.
DR PhosphoSitePlus; A2RSQ1; -.
DR PaxDb; A2RSQ1; -.
DR PRIDE; A2RSQ1; -.
DR ProteomicsDB; 268829; -. [A2RSQ1-1]
DR ProteomicsDB; 268830; -. [A2RSQ1-2]
DR GeneID; 70893; -.
DR KEGG; mmu:70893; -.
DR UCSC; uc009opw.2; mouse. [A2RSQ1-1]
DR CTD; 112937; -.
DR MGI; MGI:1918143; Glb1l3.
DR eggNOG; KOG0496; Eukaryota.
DR InParanoid; A2RSQ1; -.
DR OrthoDB; 179316at2759; -.
DR PhylomeDB; A2RSQ1; -.
DR BioGRID-ORCS; 70893; 2 hits in 19 CRISPR screens.
DR PRO; PR:A2RSQ1; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; A2RSQ1; protein.
DR GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR GO; GO:0004565; F:beta-galactosidase activity; IBA:GO_Central.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR InterPro; IPR026283; B-gal_1-like.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR019801; Glyco_hydro_35_CS.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR23421; PTHR23421; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PIRSF; PIRSF006336; B-gal; 1.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF51445; SSF51445; 1.
DR PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycosidase; Hydrolase; Reference proteome.
FT CHAIN 1..649
FT /note="Beta-galactosidase-1-like protein 3"
FT /id="PRO_0000283029"
FT ACT_SITE 203
FT /note="Proton donor"
FT /evidence="ECO:0000250"
FT ACT_SITE 277
FT /note="Nucleophile"
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..63
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024289"
SQ SEQUENCE 649 AA; 73922 MW; D1DDD9444628C747 CRC64;
MAIFFLPTVL SGFAPHSEEV FKSPARFSWS NLTPSELKNR FVGLSTKTNA LGKAYFTLEG
HKFMIVGGSI HYFRVPREYW KDRLLKLQAC GFNTVTTYIP WNLHEQERGK FDFSEILDLE
AYVLLAKTIG LWVILRPGPY ICAEVDLGGL PSWLLRNPVT DLRTTNKGFI EAVDKYFDHL
IPKILPLQYR HGGPVIAVQV ENEYGSFQKD RNYMNYLKKA LLKRGIVELL LTSDDKDGIQ
IGSVNGALTT INMNSFTKDS FIKLHKMQSD KPIMIMEYWT GWYDSWGSKH IEKSAEEIRH
TVYKFISYGL SFNMYMFHGG TNFGFINGGR YENHHISVVT SYDYDAVLSE AGDYTEKYFK
LRKLFASGSA RPLPPLPPLI PKAIYPSVNL SFYLPLFDIL PYLNQPVMLH TPVTMENLPI
NNGSGQPFGL VLYETSICSG GSLFASVHDS AQVFLNDQSI GILDENHEVL QIPKIQGCQL
LRILVENQGR INYSWRIQSE QKGLKEVVSI DGLLLTNFTI YSLDMKMSFF KRLRSASWRL
APKTYNGPAF YWGILNAGSS PTDTFLHLPN WHYGFVFING RNLGRYWDIG PQRTLYLPGP
WLHPEDNEVI VFEKIEKGFD IQTRKKPQLQ ECYETGSGLP DAAGDADPC
