ID   GLBL_LAMSP              Reviewed;         224 AA.
AC   P16222;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Giant hemoglobin linker AV-1 chain;
OS   Lamellibrachia sp. (Deep-sea giant tube worm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC   Sedentaria; Canalipalpata; Sabellida; Siboglinidae; Lamellibrachia;
OC   unclassified Lamellibrachia.
OX   NCBI_TaxID=6424;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2295645; DOI=10.1016/s0021-9258(19)40052-5;
RA   Suzuki T., Takagi T., Ohta S.;
RT   "Primary structure of a linker subunit of the tube worm 3000-kDa
RT   hemoglobin.";
RL   J. Biol. Chem. 265:1551-1555(1990).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-41.
RX   PubMed=3202832;
RA   Suzuki T., Takagi T., Ohta S.;
RT   "N-terminal amino acid sequence of the deep-sea tube worm haemoglobin
RT   remarkably resembles that of annelid haemoglobin.";
RL   Biochem. J. 255:541-545(1988).
CC   -!- FUNCTION: Acts as a linker for the assembly of heme-containing chains
CC       in the construction of giant hemoglobin.
CC   -!- SUBUNIT: Giant hemoglobin is composed of four heme-containing chains
CC       (AI to AIV), and two linker chains (AV and AVI).
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DR   PIR; A35012; A35012.
DR   AlphaFoldDB; P16222; -.
DR   SMR; P16222; -.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd11673; hemoglobin_linker_C; 1.
DR   CDD; cd00112; LDLa; 1.
DR   InterPro; IPR031639; Eryth_link_C.
DR   InterPro; IPR036153; Eryth_link_C_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   Pfam; PF16915; Eryth_link_C; 1.
DR   SMART; SM00192; LDLa; 1.
DR   SUPFAM; SSF141480; SSF141480; 1.
DR   SUPFAM; SSF57424; SSF57424; 1.
DR   PROSITE; PS01209; LDLRA_1; 1.
DR   PROSITE; PS50068; LDLRA_2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Glycoprotein; Oxygen transport;
KW   Transport.
FT   CHAIN           1..224
FT                   /note="Giant hemoglobin linker AV-1 chain"
FT                   /id="PRO_0000087500"
FT   DOMAIN          62..103
FT                   /note="LDL-receptor class A"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   CARBOHYD        108
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000305"
FT   DISULFID        64..77
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DISULFID        71..90
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT   DISULFID        84..101
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
SQ   SEQUENCE   224 AA;  24895 MW;  89FB924D4D76AAEC CRC64;
     AAVQPLSVSD AMGARVDAQA WRVDRLTKQF QAISDAADTS IGAAKSGGDI ARHMLNSHLD
     DHWCPSKYHR CGNSPQCMSN MAFCDGVNDC KNHFDEDENR CVVPVTANST WIGYPAYDHC
     TQRRPYEMVI SITSAPSDIV YKVHQPLKVQ VDLFSKKGGL KQSASLHGDA VYCKGSQRLI
     VAPPEDDRLE IIGQFDGVSN DRFKGYIVRE MSGDKCAEFR FFKQ