GLBL_TYLHE
ID GLBL_TYLHE Reviewed; 253 AA.
AC P18207;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=Giant extracellular hemoglobin linker 1 chain;
OS Tylorrhynchus heterochaetus (Marine worm) (Nereis heterochaeta).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Polychaeta;
OC Errantia; Phyllodocida; Nereididae; Tylorrhynchus.
OX NCBI_TaxID=6361;
RN [1]
RP PROTEIN SEQUENCE.
RX PubMed=2373687; DOI=10.1016/s0021-9258(19)38327-9;
RA Suzuki T., Takagi T., Gotoh T.;
RT "Primary structure of two linker chains of the extracellular hemoglobin
RT from the polychaete Tylorrhynchus heterochaetus.";
RL J. Biol. Chem. 265:12168-12177(1990).
CC -!- FUNCTION: Acts as a linker for the assembly of heme-containing chains
CC in the construction of giant hemoglobin.
CC -!- SUBUNIT: Disulfide-linked dimer of identical chains. A model is
CC proposed for the subunit structure of the Tylorrhynchus hemoglobin,
CC consisting of 216 polypeptide chains, 192 heme-containing chains, and
CC 24 linker chains.
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DR PIR; A36564; A36564.
DR AlphaFoldDB; P18207; -.
DR SMR; P18207; -.
DR GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR CDD; cd11673; hemoglobin_linker_C; 1.
DR CDD; cd00112; LDLa; 1.
DR InterPro; IPR031639; Eryth_link_C.
DR InterPro; IPR036153; Eryth_link_C_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR Pfam; PF16915; Eryth_link_C; 1.
DR SMART; SM00192; LDLa; 1.
DR SUPFAM; SSF141480; SSF141480; 1.
DR SUPFAM; SSF57424; SSF57424; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Oxygen transport; Transport.
FT CHAIN 1..253
FT /note="Giant extracellular hemoglobin linker 1 chain"
FT /id="PRO_0000087501"
FT DOMAIN 89..131
FT /note="LDL-receptor class A"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 91..105
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 98..118
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
FT DISULFID 112..129
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 253 AA; 28200 MW; 461EBBD16DF1B805 CRC64;
GALGDRNGDC ACDRPSPRGY WGGGMTGRSA FADPHIAEGR LANQDARLGT LEEEVDKLQH
KYDDFIAGKT ARRERFAQLK DRVWGLEAHH CDDDHLSCKD VAFTCIGHNL VCDGHKDCLN
GHDEDEETCS IAASVGSSFE GQIRQLDTCT KRKPSAFRFI ITNVDVPKYF PQEPHVKATI
LMTSSKDGHE TQSSLAVDGV YDFTHRKVIL YSPDKDNLIF ECTFPRHDNN HCKGVMKHSG
GDVCLTFTLE RID