ID   GLB_ISOHY               Reviewed;         149 AA.
AC   P80722;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Globin;
DE   AltName: Full=Myoglobin;
OS   Isoparorchis hypselobagri (Giant trematode).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Azygiida; Isoparorchiidae; Isoparorchis.
OX   NCBI_TaxID=36663;
RN   [1]
RP   PROTEIN SEQUENCE OF 2-149.
RX   PubMed=9006947; DOI=10.1074/jbc.272.5.2992;
RA   Rashid A.R., van Hauwaert M.-L., Haque M., Siddiqi A.H., Lasters I.,
RA   de Maeyer M., Griffon N., Marden M.C., Dewilde S., Clauwaert J.,
RA   Vinogradov S.N., Moens L.;
RT   "Trematode myoglobins, functional molecules with a distal tyrosine.";
RL   J. Biol. Chem. 272:2992-2999(1997).
CC   -!- FUNCTION: Oxygen binding protein.
CC   -!- SUBUNIT: Monomer.
CC   -!- MISCELLANEOUS: This globin lacks one of the heme-binding histidine
CC       residues found in most other globins (replaced by tyrosine) but is
CC       functional despite this change.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000305}.
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DR   PIR; B58345; B58345.
DR   AlphaFoldDB; P80722; -.
DR   SMR; P80722; -.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd01040; Mb-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR011406; Globin_trematode.
DR   InterPro; IPR044399; Mb-like_M.
DR   Pfam; PF00042; Globin; 1.
DR   PIRSF; PIRSF036488; Myoglobin_tremt; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..149
FT                   /note="Globin"
FT                   /id="PRO_0000052465"
FT   BINDING         100
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
SQ   SEQUENCE   149 AA;  16648 MW;  ED1EF7799A8EEE8C CRC64;
     MVLTKDEFDS LLHELDPKID TEEHRMELGL GAYTELFAAH PEYIKKFSRL QEATPANVMA
     QDGAKYYAKT LINDLVELLK ASTDEATLNT AIARTATKDH KPRNVSGAEF QTGEPIFIKY
     FSHVLTTPAN QAFMEKLLTK IFTGVAGQL