ID   GLB_LAMFL               Reviewed;         150 AA.
AC   P02207;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Globin;
OS   Lampetra fluviatilis (European river lamprey) (Petromyzon fluviatilis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata;
OC   Hyperoartia; Petromyzontiformes; Petromyzontidae; Lampetra.
OX   NCBI_TaxID=7748;
RN   [1]
RP   PROTEIN SEQUENCE OF 2-150.
RX   PubMed=118914;
RA   Zelenik M., Rudloff V., Braunitzer G.;
RT   "Hemoglobins, XXX. The amino acid sequence of the monomeric hemoglobin from
RT   Lampetra fluviatilis.";
RL   Hoppe-Seyler's Z. Physiol. Chem. 360:1879-1894(1979).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH HEME.
RA   Seki M., Yao M., Yazawa Y., Tanaka I.;
RT   "Crystal structure analysis of river lamprey hemoglobin I.";
RL   Submitted (APR-2003) to the PDB data bank.
CC   -!- SUBUNIT: Monomer. {ECO:0000269|Ref.2}.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; A02528; GGLMF.
DR   PDB; 1UC3; X-ray; 2.30 A; A/B/C/D/E/F/G/H/I/J/K/L=2-150.
DR   PDBsum; 1UC3; -.
DR   AlphaFoldDB; P02207; -.
DR   SMR; P02207; -.
DR   EvolutionaryTrace; P02207; -.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR013314; Globin_lamprey/hagfish.
DR   PANTHER; PTHR46783; PTHR46783; 1.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR01906; FISHGLOBIN.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Heme; Iron; Metal-binding;
KW   Oxygen transport; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..150
FT                   /note="Globin"
FT                   /id="PRO_0000052525"
FT   BINDING         74
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         106
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT   STRAND          5..7
FT                   /evidence="ECO:0007829|PDB:1UC3"
FT   HELIX           14..28
FT                   /evidence="ECO:0007829|PDB:1UC3"
FT   HELIX           31..45
FT                   /evidence="ECO:0007829|PDB:1UC3"
FT   HELIX           47..49
FT                   /evidence="ECO:0007829|PDB:1UC3"
FT   HELIX           54..56
FT                   /evidence="ECO:0007829|PDB:1UC3"
FT   HELIX           62..67
FT                   /evidence="ECO:0007829|PDB:1UC3"
FT   HELIX           69..86
FT                   /evidence="ECO:0007829|PDB:1UC3"
FT   TURN            87..90
FT                   /evidence="ECO:0007829|PDB:1UC3"
FT   HELIX           92..108
FT                   /evidence="ECO:0007829|PDB:1UC3"
FT   HELIX           117..129
FT                   /evidence="ECO:0007829|PDB:1UC3"
FT   HELIX           133..145
FT                   /evidence="ECO:0007829|PDB:1UC3"
FT   TURN            146..149
FT                   /evidence="ECO:0007829|PDB:1UC3"
SQ   SEQUENCE   150 AA;  16404 MW;  4283FAB47706A0EC CRC64;
     MPIVDSGSVA PLSAAEKTKI RSAWAPVYSN YETSGVDILV KFFTSTPAAQ EFFPKFKGMT
     SADQLKKSAD VRWHAERIIN AVNDAVASMD DTEKMSMKLR DLSGKHAKSF QVDPQYFKVL
     AAVIADTVAA GDAGFEKLMS MICILLRSAY