ID   GLB_TUBTU               Reviewed;         141 AA.
AC   P18202;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Globin, extracellular monomeric;
OS   Tubifex tubifex (Sludge worm) (Lumbricus tubifex).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Oligochaeta; Tubificida; Tubificina; Naididae; Tubificinae; Tubifex.
OX   NCBI_TaxID=6386;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2253625; DOI=10.1111/j.1432-1033.1990.tb19428.x;
RA   Stern M.S., Vinogradov S.N., Sharma P.K., Ereifej K., Walz D.A.;
RT   "Amino acid sequence of the monomer subunit of the giant extracellular
RT   hemoglobin of the aquatic oligochaete, Tubifex tubifex.";
RL   Eur. J. Biochem. 194:67-73(1990).
CC   -!- SUBUNIT: The giant hemoglobins of worms are formed of a monomeric
CC       subunit and a disulfide-bonded trimer. This subunit is monomeric.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   PIR; S13836; S13836.
DR   AlphaFoldDB; P18202; -.
DR   SMR; P18202; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005833; C:hemoglobin complex; IEA:InterPro.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0019825; F:oxygen binding; IEA:InterPro.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   CDD; cd01040; Mb-like; 1.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR002336; Erythrocruorin.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR014610; Haemoglobin_extracell.
DR   InterPro; IPR044399; Mb-like_M.
DR   Pfam; PF00042; Globin; 1.
DR   PIRSF; PIRSF036517; Ext_hemo; 1.
DR   PRINTS; PR00611; ERYTHCRUORIN.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Heme; Iron; Metal-binding;
KW   Oxygen transport; Secreted; Transport.
FT   CHAIN           1..141
FT                   /note="Globin, extracellular monomeric"
FT                   /id="PRO_0000052511"
FT   BINDING         94
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   DISULFID        2..131
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   141 AA;  15922 MW;  4BA1A1331B0C2A88 CRC64;
     ECDALQRFKV KHQWAEAFGT SHHRLDFGLK LWNSIFRDAP EIRGLFKRVD GDNAYSAEFE
     AHAERVLGGL DMTISLLDDQ AAFDAQLAHL KSQHAERNIK ADYYGVFVNE LLAVLPDYLG
     TKLDFKAWSE CLGVITGAIH D