ID   GLCC_ECOL6              Reviewed;         254 AA.
AC   P0ACL6; P52072;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 89.
DE   RecName: Full=Glc operon transcriptional activator {ECO:0000250|UniProtKB:P0ACL5};
DE   AltName: Full=Glc regulatory protein {ECO:0000250|UniProtKB:P0ACL5};
DE   AltName: Full=HTH-type transcriptional regulator GlcC;
GN   Name=glcC; OrderedLocusNames=c3710;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Transcriptional activator of the glcDEFGB operon which is
CC       associated with glycolate utilization, and encodes malate synthase G
CC       and the genes needed for glycolate oxidase activity. Also negatively
CC       regulates the transcription of its own gene. Glycolate acts as an
CC       effector, but GlcC can also use acetate as an alternative effector.
CC       {ECO:0000250|UniProtKB:P0ACL5}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN82154.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN82154.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001297764.1; NC_004431.1.
DR   AlphaFoldDB; P0ACL6; -.
DR   SMR; P0ACL6; -.
DR   STRING; 199310.c3710; -.
DR   EnsemblBacteria; AAN82154; AAN82154; c3710.
DR   GeneID; 66673130; -.
DR   KEGG; ecc:c3710; -.
DR   eggNOG; COG2186; Bacteria.
DR   HOGENOM; CLU_017584_9_1_6; -.
DR   OMA; EHINGIR; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..254
FT                   /note="Glc operon transcriptional activator"
FT                   /id="PRO_0000050646"
FT   DOMAIN          6..74
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        34..53
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   254 AA;  28826 MW;  984C172F18886BF5 CRC64;
     MKDERRPICE VVAESIERLI IDGVLKVGQP LPSERRLCEK LGFSRSALRE GLTVLRGRGI
     IETAQGRDSR VARLNRVQDT SPLIHLFSTQ PRTLYDLLDV RALLEGESAR LAATLGTQAD
     FVVITRCYEK MLAASENNKE ISLIEHAQLD HAFHLAICQA SHNQVLVFTL QSLTDLMFNS
     VFASVNNLYH RPQQKKQIDR QHARIYNAVL QRLPHVAQRA ARDHVRTVKK NLHDIELEGH
     HLIRSAVPLE MNLS