GLCG_ECOLI
ID GLCG_ECOLI Reviewed; 134 AA.
AC P0AEQ1; P45504; Q2M9L9;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=Protein GlcG;
GN Name=glcG {ECO:0000303|PubMed:8606183}; Synonyms=yghC;
GN OrderedLocusNames=b2977, JW2944;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DISRUPTION PHENOTYPE.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=8606183; DOI=10.1128/jb.178.7.2051-2059.1996;
RA Pellicer M.T., Badia J., Aguilar J.T., Baldoma L.;
RT "glc locus of Escherichia coli: characterization of genes encoding the
RT subunits of glycolate oxidase and the glc regulator protein.";
RL J. Bacteriol. 178:2051-2059(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 59-134.
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=7925370; DOI=10.1111/j.1432-1033.1994.00541.x;
RA Molina I., Badia J., Aguilar J.T., Pellicer M.T., Baldoma L.;
RT "Molecular characterization of Escherichia coli malate synthase G.
RT Differentiation with the malate synthase A isoenzyme.";
RL Eur. J. Biochem. 224:541-548(1994).
RN [5]
RP INDUCTION.
RC STRAIN=K12 / MC4100;
RX PubMed=9880556; DOI=10.1074/jbc.274.3.1745;
RA Pellicer M.T., Fernandez C., Badia J., Aguilar J., Lin E.C., Baldom L.;
RT "Cross-induction of glc and ace operons of Escherichia coli attributable to
RT pathway intersection. Characterization of the glc promoter.";
RL J. Biol. Chem. 274:1745-1752(1999).
CC -!- INDUCTION: Part of the glcDEFGB operon, which is induced by growth on
CC glycolate, under the positive control of GlcC. Also induced by growth
CC on acetate. Expression of the glc operon is strongly dependent on the
CC integration host factor (IHF) and is repressed by the global
CC respiratory regulator ArcA-P. {ECO:0000269|PubMed:9880556}.
CC -!- DISRUPTION PHENOTYPE: No effect on glycolate utilization.
CC {ECO:0000269|PubMed:8606183}.
CC -!- SIMILARITY: Belongs to the GlcG family. {ECO:0000305}.
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DR EMBL; L43490; AAB02533.1; -; Genomic_DNA.
DR EMBL; U28377; AAA69144.1; -; Genomic_DNA.
DR EMBL; U00096; AAC76013.1; -; Genomic_DNA.
DR EMBL; AP009048; BAE77037.1; -; Genomic_DNA.
DR EMBL; X74547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PIR; G65083; G65083.
DR RefSeq; NP_417451.1; NC_000913.3.
DR RefSeq; WP_000853256.1; NZ_STEB01000001.1.
DR AlphaFoldDB; P0AEQ1; -.
DR SMR; P0AEQ1; -.
DR BioGRID; 4263078; 9.
DR DIP; DIP-9766N; -.
DR STRING; 511145.b2977; -.
DR jPOST; P0AEQ1; -.
DR PaxDb; P0AEQ1; -.
DR PRIDE; P0AEQ1; -.
DR EnsemblBacteria; AAC76013; AAC76013; b2977.
DR EnsemblBacteria; BAE77037; BAE77037; BAE77037.
DR GeneID; 66673134; -.
DR GeneID; 947473; -.
DR KEGG; ecj:JW2944; -.
DR KEGG; eco:b2977; -.
DR PATRIC; fig|511145.12.peg.3071; -.
DR EchoBASE; EB2786; -.
DR eggNOG; COG3193; Bacteria.
DR HOGENOM; CLU_103773_1_2_6; -.
DR InParanoid; P0AEQ1; -.
DR OMA; NNWAVTI; -.
DR PhylomeDB; P0AEQ1; -.
DR BioCyc; EcoCyc:G7543-MON; -.
DR PRO; PR:P0AEQ1; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR Gene3D; 3.30.450.150; -; 1.
DR InterPro; IPR005624; PduO/GlcC-like.
DR InterPro; IPR038084; PduO/GlcC-like_sf.
DR Pfam; PF03928; Haem_degrading; 1.
DR SUPFAM; SSF143744; SSF143744; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..134
FT /note="Protein GlcG"
FT /id="PRO_0000087504"
FT CONFLICT 128..134
FT /note="AAAVLAK -> QQRCWRNKRKRGDKQ (in Ref. 4)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 134 AA; 13737 MW; 43D8A615A6E60A6A CRC64;
MKTKVILSQQ MASAIIAAGQ EEAQKNNWSV SIAVADDGGH LLALSRMDDC APIAAYISQE
KARTAALGRR ETKGYEEMVN NGRTAFVTAP LLTSLEGGVP VVVDGQIIGA VGVSGLTGAQ
DAQVAKAAAA VLAK
