GLCM1_CAMDR
ID GLCM1_CAMDR Reviewed; 155 AA.
AC P15522; Q9TTR3; Q9TUJ8;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 02-AUG-2002, sequence version 2.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Glycosylation-dependent cell adhesion molecule 1;
DE Short=GlyCAM-1;
DE AltName: Full=Lactophorin;
DE AltName: Full=Proteose-peptone component 3;
DE Short=PP3;
DE AltName: Full=Whey protein;
DE Flags: Precursor;
GN Name=GLYCAM1;
OS Camelus dromedarius (Dromedary) (Arabian camel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus.
OX NCBI_TaxID=9838;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE, ALTERNATIVE
RP SPLICING, TISSUE SPECIFICITY, AND MASS SPECTROMETRY.
RC TISSUE=Mammary gland;
RX PubMed=10531593; DOI=10.3168/jds.s0022-0302(99)75450-0;
RA Kappeler S., Farah Z., Puhan Z.;
RT "Alternative splicing of lactophorin mRNA from lactating mammary gland of
RT the camel (Camelus dromedarius).";
RL J. Dairy Sci. 82:2084-2093(1999).
RN [2]
RP PROTEIN SEQUENCE OF 19-155 (ISOFORMS A AND B).
RC TISSUE=Milk;
RX PubMed=3495459; DOI=10.1016/0014-5793(87)80704-4;
RA Beg O.U., von Bahr-Lindstroem H., Zaidi Z.H., Joernvall H.;
RT "Characterization of a heterogeneous camel milk whey non-casein protein.";
RL FEBS Lett. 216:270-274(1987).
RN [3]
RP PROTEIN SEQUENCE OF 19-147, GLYCOSYLATION AT THR-34, AND PHOSPHORYLATION AT
RP SER-57; SER-59 AND SER-65.
RC TISSUE=Milk;
RX PubMed=10735560; DOI=10.1139/o99-067;
RA Girardet J.-M., Saulnier F., Gaillard J.-L., Ramet J.-P., Humbert G.;
RT "Camel (Camelus dromedarius) milk PP3: evidence for an insertion in the
RT amino-terminal sequence of the camel milk whey protein.";
RL Biochem. Cell Biol. 78:19-26(2000).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=A;
CC IsoId=P15522-1; Sequence=Displayed;
CC Name=B;
CC IsoId=P15522-2; Sequence=VSP_005082, VSP_005083;
CC -!- TISSUE SPECIFICITY: Highly expressed in whey fraction of camel milk.
CC {ECO:0000269|PubMed:10531593}.
CC -!- MASS SPECTROMETRY: Mass=15706; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:10531593};
CC -!- MASS SPECTROMETRY: [Isoform B]: Mass=13822; Method=MALDI; Note=The
CC measured range is 19-140.; Evidence={ECO:0000269|PubMed:10531593};
CC -!- SIMILARITY: Belongs to the PP3/GlyCAM-1 family. {ECO:0000305}.
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DR EMBL; AJ131714; CAB53388.1; -; Genomic_DNA.
DR EMBL; AJ131714; CAB53389.1; -; Genomic_DNA.
DR PIR; S00006; S00006.
DR AlphaFoldDB; P15522; -.
DR SMR; P15522; -.
DR STRING; 9838.ENSCDRP00005015177; -.
DR iPTMnet; P15522; -.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR InterPro; IPR007906; GLYCAM-1.
DR Pfam; PF05242; GLYCAM-1; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Direct protein sequencing; Glycoprotein;
KW Phosphoprotein; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000269|PubMed:10735560"
FT CHAIN 19..155
FT /note="Glycosylation-dependent cell adhesion molecule 1"
FT /id="PRO_0000025410"
FT REGION 74..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 48
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P80195"
FT MOD_RES 53
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P80195"
FT MOD_RES 57
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:10735560"
FT MOD_RES 59
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:10735560"
FT MOD_RES 65
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:10735560"
FT CARBOHYD 34
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000269|PubMed:10735560"
FT VAR_SEQ 22..36
FT /note="Missing (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_005082"
FT VAR_SEQ 37
FT /note="S -> A (in isoform B)"
FT /evidence="ECO:0000305"
FT /id="VSP_005083"
FT CONFLICT 26..27
FT /note="EI -> IM (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 31..55
FT /note="Missing (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 126
FT /note="I -> L (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 155 AA; 17292 MW; E0DAFB7BB35F2B43 CRC64;
MKFFAVLLLA SLAATSLASL NEPKDEIYME SQPTDTSAQV IMSNHQVSSE DLSMEPSISR
EDLVSKDDVV IKSARRHQNQ NPKLLHPVPQ ESSFRNTATQ SEETKELTPG AATTLEGKLV
ELTHKIIKNL ENTMRETMDF LKSLFPHASE VVKPQ
