ID   GLCM1_CAPHI             Reviewed;         154 AA.
AC   P81447; Q9BDC6;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2002, sequence version 2.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Glycosylation-dependent cell adhesion molecule 1;
DE            Short=GlyCAM-1;
DE   AltName: Full=28 kDa milk glycoprotein PP3;
DE   AltName: Full=Lactophorin;
DE   AltName: Full=Proteose-peptone component 3;
DE            Short=PP3;
DE   Flags: Precursor;
GN   Name=GLYCAM1;
OS   Capra hircus (Goat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Capra.
OX   NCBI_TaxID=9925;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=12957379; DOI=10.1016/s0378-1119(03)00632-2;
RA   Le Provost F., Cassy S., Hayes H., Martin P.;
RT   "Structure and expression of goat GLYCAM1 gene: lactogenic-dependent
RT   expression in ruminant mammary gland and interspecies conservation of the
RT   proximal promoter.";
RL   Gene 313:83-89(2003).
RN   [2]
RP   PROTEIN SEQUENCE OF 19-154, PHOSPHORYLATION AT SER-48 AND SER-59, AND
RP   GLYCOSYLATION AT THR-34 AND ASN-96.
RC   TISSUE=Milk;
RX   PubMed=9749374; DOI=10.3168/jds.s0022-0302(98)75786-8;
RA   Lister I.M.B., Rasmussen L.K., Johnsen L.B., Moeller L., Petersen T.E.,
RA   Soerensen E.S.;
RT   "The primary structure of caprine PP3: amino acid sequence,
RT   phosphorylation, and glycosylation of component PP3 from the proteose-
RT   peptone fraction of caprine milk.";
RL   J. Dairy Sci. 81:2111-2115(1998).
CC   -!- SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
CC   -!- TISSUE SPECIFICITY: Highly and specifically expressed in the lactating
CC       mammary gland.
CC   -!- SIMILARITY: Belongs to the PP3/GlyCAM-1 family. {ECO:0000305}.
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DR   EMBL; AJ249734; CAC37334.1; -; mRNA.
DR   EMBL; AJ249733; CAC37333.1; -; Genomic_DNA.
DR   RefSeq; NP_001272555.1; NM_001285626.1.
DR   AlphaFoldDB; P81447; -.
DR   SMR; P81447; -.
DR   STRING; 9925.ENSCHIP00000011297; -.
DR   iPTMnet; P81447; -.
DR   PRIDE; P81447; -.
DR   GeneID; 100860769; -.
DR   KEGG; chx:100860769; -.
DR   CTD; 644076; -.
DR   OrthoDB; 1585143at2759; -.
DR   Proteomes; UP000291000; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR   InterPro; IPR007906; GLYCAM-1.
DR   Pfam; PF05242; GLYCAM-1; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Membrane; Phosphoprotein;
KW   Reference proteome; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000269|PubMed:9749374"
FT   CHAIN           19..154
FT                   /note="Glycosylation-dependent cell adhesion molecule 1"
FT                   /id="PRO_0000025409"
FT   REGION          51..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..68
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        71..86
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..112
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         48
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:9749374"
FT   MOD_RES         53
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P80195"
FT   MOD_RES         57
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P80195"
FT   MOD_RES         59
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:9749374"
FT   MOD_RES         65
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P80195"
FT   CARBOHYD        34
FT                   /note="O-linked (GalNAc...) threonine; partial"
FT                   /evidence="ECO:0000269|PubMed:9749374"
FT   CARBOHYD        96
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000269|PubMed:9749374"
SQ   SEQUENCE   154 AA;  17056 MW;  AB9B33AE3E955814 CRC64;
     MKFLCILLLA SLAATSLAIL NEPEDETHLE AQPTDASAQF IISNLQISTE DLSKEPSISR
     EDLISKEPNV IRSPRQPQNQ NPKLPLSILK EKQLRNATLG SEETTEHAPS DASTTEGKLM
     ELGHKIMKNL ENTVKEIIKY LKSLFPPASE VVKP