ID   GLCP_BACSU              Reviewed;         401 AA.
AC   O07563; Q796S3;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Glucose/mannose transporter GlcP;
DE   AltName: Full=Glucose/mannose:H(+) symporter;
GN   Name=glcP; Synonyms=glcT1, yhjI; OrderedLocusNames=BSU10520;
OS   Bacillus subtilis (strain 168).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=224308;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION AS A SYMPORTER, AND INDUCTION.
RC   STRAIN=168 / GM273;
RX   PubMed=9457850; DOI=10.1128/jb.180.3.498-504.1998;
RA   Paulsen I.T., Chauvaux S., Choi P., Saier M.H. Jr.;
RT   "Characterization of glucose-specific catabolite repression-resistant
RT   mutants of Bacillus subtilis: identification of a novel hexose:H+
RT   symporter.";
RL   J. Bacteriol. 180:498-504(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=168;
RA   Noback M.A., Terpstra P., Holsappel S., Venema G., Bron S.;
RL   Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=168;
RX   PubMed=9384377; DOI=10.1038/36786;
RA   Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA   Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA   Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA   Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA   Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA   Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA   Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA   Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA   Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA   Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA   Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA   Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA   Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA   Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA   Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA   Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA   Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA   Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA   Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA   Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA   Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA   Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA   Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA   Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA   Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA   Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA   Yoshikawa H., Danchin A.;
RT   "The complete genome sequence of the Gram-positive bacterium Bacillus
RT   subtilis.";
RL   Nature 390:249-256(1997).
RN   [4]
RP   FUNCTION.
RX   PubMed=17056753; DOI=10.1128/jb.01478-06;
RA   Inaoka T., Ochi K.;
RT   "Glucose uptake pathway-specific regulation of synthesis of
RT   neotrehalosadiamine, a novel autoinducer produced in Bacillus subtilis.";
RL   J. Bacteriol. 189:65-75(2007).
CC   -!- FUNCTION: Can transport glucose, mannose, 2-deoxyglucose and methyl
CC       alpha-glucoside, but not galactose. {ECO:0000269|PubMed:17056753,
CC       ECO:0000269|PubMed:9457850}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Induced by glucose. Induction depends upon the integrity of
CC       the glucose-specific PTS system. {ECO:0000269|PubMed:9457850}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AF002191; AAC38133.1; -; Genomic_DNA.
DR   EMBL; Y14081; CAA74471.1; -; Genomic_DNA.
DR   EMBL; AL009126; CAB12892.1; -; Genomic_DNA.
DR   PIR; H69833; H69833.
DR   RefSeq; NP_388933.1; NC_000964.3.
DR   RefSeq; WP_003245772.1; NZ_JNCM01000035.1.
DR   AlphaFoldDB; O07563; -.
DR   SMR; O07563; -.
DR   STRING; 224308.BSU10520; -.
DR   TCDB; 2.A.1.7.3; the major facilitator superfamily (mfs).
DR   PaxDb; O07563; -.
DR   PRIDE; O07563; -.
DR   EnsemblBacteria; CAB12892; CAB12892; BSU_10520.
DR   GeneID; 936346; -.
DR   KEGG; bsu:BSU10520; -.
DR   PATRIC; fig|224308.179.peg.1131; -.
DR   eggNOG; COG0738; Bacteria.
DR   InParanoid; O07563; -.
DR   OMA; RFGFVLM; -.
DR   PhylomeDB; O07563; -.
DR   BioCyc; BSUB:BSU10520-MON; -.
DR   Proteomes; UP000001570; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..401
FT                   /note="Glucose/mannose transporter GlcP"
FT                   /id="PRO_0000375919"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        43..63
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        212..232
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        336..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   401 AA;  44910 MW;  BB7177EB27924D36 CRC64;
     MLRGTYLFGY AFFFTVGIIH ISTGSLTPFL LEAFNKTTDD ISVIIFFQFT GFLSGVLIAP
     LMIKKYSHFR TLTLALTIML VALSIFFLTK DWYYIIVMAF LLGYGAGTLE TTVGSFVIAN
     FESNAEKMSK LEVLFGLGAL SFPLLINSFI DINNWFLPYY CIFTFLFVLF VGWLIFLSKN
     REYAKNANQQ VTFPDGGAFQ YFIGDRKKSK QLGFFVFFAF LYAGIETNFA NFLPSIMINQ
     DNEQISLISV SFFWVGIIIG RILIGFVSRR LDFSKYLLFS CSCLIVLLIA FSYISNPILQ
     LSGTFLIGLS IAGIFPIALT LASIIIQKYV DEVTSLFIAS ASFGGAIISF LIGWSLNQDT
     ILLTMGIFTT MAVILVGISV KIRRTKTEDP ISLENKASKT Q